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ChEMBL ligand: CHEMBL340800 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
ChEMBL | Inhibition of human neuronal Nitric Oxide Synthase | B | 4.43 | pIC50 | 37000 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 597-600 [PMID:10741561] |
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
ChEMBL | Inhibition of human endothelial Nitric Oxide Synthase | B | 4.11 | pIC50 | 78000 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 597-600 [PMID:10741561] |
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
GtoPdb | - | - | 5.5 | pIC50 | 3160 | nM | IC50 | J Med Chem (1994) 37: 3886-8 [PMID:7525961] |
ChEMBL | Inhibition of human inducible nitric oxide synthase | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 597-600 [PMID:10741561] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]