JNJ1661010 [Ligand Id: 5206] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL460273 (JNJ-1661010) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of human FAAH preincubated for 10 mins | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Inhibition of human FAAH preincubated for 20 mins | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Inhibition of FAAH | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4241-4244 [PMID:19515560] |
| ChEMBL | Inhibition of FAAH | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4674-4685 [PMID:21764305] |
| GtoPdb | - | - | 7.8 | pIC50 | 15.8 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-43 [PMID:18693015] |
| ChEMBL | Inhibition of human FAAH preincubated for 40 mins | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Inhibition of human FAAH after 60 mins | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Apparent inhibition of human FAAH expressed in CHO-K1 cells using ethanolamine 1-3[H] as substrate after 30 mins by liquid scintillation counting | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem (2013) 21: 28-41 [PMID:23218778] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| ChEMBL | Inhibition of rat FAAH preincubated for 20 mins | B | 7.47 | pIC50 | 34 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4838-4843 [PMID:18693015] |
| ChEMBL | Inhibition of rat FAAH | B | 7.47 | pIC50 | 34 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4674-4685 [PMID:21764305] |
| ChEMBL | Inhibition of rat FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarin | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2492-2496 [PMID:21392988] |
| Fatty acid amide hydrolase-2 in Human [GtoPdb: 1401] [UniProtKB: Q6GMR7] | ||||||||
| GtoPdb | 20 min preincubation | - | 5.24 | pIC50 | 5700 | nM | IC50 | Anesth Analg (2009) 108: 316-29 [PMID:19095868] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
