ChEMBL ligand: CHEMBL267473 (Dazoxiben, UK-37248)
CYP11B1/Cytochrome P450 11B1 in Rat [ChEMBL: CHEMBL4970] [GtoPdb: 1359] [UniProtKB: P15393] There should be some charts here, you may need to enable JavaScript!
CYP8A1/Prostaglandin I2 synthase in Human [ChEMBL: CHEMBL4428] [GtoPdb: 1356] [UniProtKB: Q16647] There should be some charts here, you may need to enable JavaScript!
CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] CYP5A1/Thromboxane-A synthase in Rat [ChEMBL: CHEMBL4028] [GtoPdb: 1353] [UniProtKB: P49430] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP11B1/Cytochrome P450 11B1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4970] [GtoPdb: 1359] [UniProtKB: P15393]
ChEMBL	Inhibition of rat adrenal 11-beta-hydroxylase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1986) 29: 1643-1650 [PMID:3091830]
ChEMBL	Inhibition of rat adrenal 11-beta-hydroxylase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1985) 28: 1427-1432 [PMID:3930740]
ChEMBL	Inhibition of 11 beta-hydroxylase from rat adrenal gland	B	4	pIC50	>100000	nM	IC50	J Med Chem (1986) 29: 342-346 [PMID:3081722]
CYP8A1/Prostaglandin I2 synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4428] [GtoPdb: 1356] [UniProtKB: Q16647]
ChEMBL	Inhibition of porcine aorta prostacyclin PGI-2 synthetase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1986) 29: 1643-1650 [PMID:3091830]
ChEMBL	Inhibition of porcine aorta prostacyclin PGI-2 synthase	B	4	pIC50	>100000	nM	IC50	J Med Chem (1985) 28: 1427-1432 [PMID:3930740]
ChEMBL	Inhibition of PGI-2 synthetase from porcine aorta	B	4	pIC50	>100000	nM	IC50	J Med Chem (1986) 29: 342-346 [PMID:3081722]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
ChEMBL	Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg	B	5.6	pIC50	2500	nM	IC50	J Med Chem (1990) 33: 646-652 [PMID:2299629]
ChEMBL	Tested for inhibitory activity against intact human platelet TXA2 formation	F	5.89	pIC50	1290	nM	IC50	J Med Chem (1987) 30: 1588-1595 [PMID:3305945]
ChEMBL	Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.	F	5.89	pIC50	1290	nM	IC50	J Med Chem (1987) 30: 1812-1818 [PMID:3656356]
ChEMBL	Inhibition of Thromboxane-A synthase	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2000) 43: 1841-1851 [PMID:10794700]
ChEMBL	Inhibition of thromboxane synthase P450 TXA2	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2000) 43: 4437-4445 [PMID:11087568]
ChEMBL	Inhibition of platelet microsomal thromboxane A synthetase in humans	B	6.21	pIC50	620	nM	IC50	J Med Chem (1989) 32: 1265-1272 [PMID:2724299]
ChEMBL	Inhibitory activity to inhibit Inophore-induced arachidonic acid metabolism (inhibition of TXB2 formation) in rat	F	6.52	pIC50	300	nM	IC50	J Med Chem (1989) 32: 1842-1860 [PMID:2547071]
ChEMBL	Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets	B	6.6	pIC50	250	nM	IC50	J Med Chem (1987) 30: 185-193 [PMID:2879917]
ChEMBL	Inhibition of platelet microsomal thromboxane A synthetase in rabbits	B	6.97	pIC50	106	nM	IC50	J Med Chem (1989) 32: 1265-1272 [PMID:2724299]
ChEMBL	In vitro inhibitory activity against human microsomal thromboxane synthase.	B	7.15	pIC50	70	nM	IC50	J Med Chem (1995) 38: 1608-1628 [PMID:7752186]
ChEMBL	In vitro inhibition of Thromboxane synthase using [14C]arachidonic acid as radioligand	B	7.55	pIC50	28	nM	IC50	J Med Chem (1991) 34: 1790-1797 [PMID:1829485]
GtoPdb	-	-	8.5	pIC50	-	-	-	Thromb Res (1981) 23: 145-62 [PMID:6795753]
ChEMBL	Inhibition of TXA2 synthetase from human platelets	B	8.52	pIC50	3	nM	IC50	J Med Chem (1986) 29: 342-346 [PMID:3081722]
ChEMBL	Inhibition of thromboxane TXA2 synthetase from human platelets	B	8.52	pIC50	3	nM	IC50	J Med Chem (1986) 29: 1643-1650 [PMID:3091830]
ChEMBL	Inhibitory activity against thromboxane A2 synthetase	B	8.52	pIC50	3	nM	IC50	J Med Chem (1985) 28: 1427-1432 [PMID:3930740]
ChEMBL	In vitro inhibition of thromboxane synthase from human platelets.	B	8.52	pIC50	3	nM	IC50	J Med Chem (1986) 29: 1637-1643 [PMID:3746813]
CYP5A1/Thromboxane-A synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4028] [GtoPdb: 1353] [UniProtKB: P49430]
ChEMBL	Inhibition of thromboxane formation at a concentration of 10e -6 M.	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1987) 30: 1036-1040 [PMID:3585902]
ChEMBL	Compound was tested for inhibitory activity against thromboxane synthetase	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1986) 29: 523-530 [PMID:3959030]
ChEMBL	Compound was tested for the inhibition of thromboxane formation (thromboxane synthetase) in platelets at a concentration of 10e-4 M	F	5.82	pIC50	1500	nM	IC50	J Med Chem (1986) 29: 816-819 [PMID:3517332]
ChEMBL	In vitro inhibition of thromboxane B2 production in rat whole blood.	F	5.92	pIC50	1200	nM	IC50	J Med Chem (1993) 36: 2964-2972 [PMID:8411014]
ChEMBL	Tested for inhibition of thromboxane synthetase from spontaneously hypertensive rats	B	6.82	pIC50	150	nM	IC50	J Med Chem (1987) 30: 2277-2283 [PMID:3681898]
ChEMBL	Inhibition of thromboxane A2 synthetase	B	6.97	pIC50	106	nM	IC50	J Med Chem (1989) 32: 1265-1272 [PMID:2724299]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]