ChEMBL ligand: CHEMBL1096979 (Benserazide, Benserazide (as hydrochloride), Benserazide hcl, Benserazide hydrochloride, NSC-755907, RO 4-4602, RO-4-4602, Serazide)
Genome polyprotein in Coxsackievirus B3 (strain Nancy) [ChEMBL: CHEMBL2396505] [UniProtKB: P03313] There should be some charts here, you may need to enable JavaScript!
Hexokinase type II in Human [ChEMBL: CHEMBL2640] [UniProtKB: P52789] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Cystathionine β-synthase in Human [GtoPdb: 1443] [UniProtKB: P35520] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Genome polyprotein in Coxsackievirus B3 (strain Nancy) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396505] [UniProtKB: P03313]
ChEMBL	Inhibition of recombinant Coxsackievirus B3 3C protease expressed in Escherichia coli BL21 (DE3) preincubated for 5 mins followed by addition of NMA-EALFQGPPVK-DNP-rrr-NH2 as substrate measured every 10 mins for 2 hrs by FRET-based enzyme assay	B	5.62	pIC50	2400	nM	IC50	Eur J Med Chem (2016) 120: 202-216 [PMID:27191615]
Hexokinase type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2640] [UniProtKB: P52789]
ChEMBL	Inhibition of HK2 (unknown origin) using glucose-6-phosphate dehydrogenase as substrate preincubated for 10 mins followed by substrate addition	B	5.26	pIC50	5520	nM	IC50	J Nat Prod (2019) 82: 1114-1119 [PMID:31013087]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate	F	6.85	pIC50	140	nM	IC50	Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
Cystathionine β-synthase in Human [GtoPdb: 1443] [UniProtKB: P35520]
GtoPdb	-	-	4.52	pIC50	~30000	nM	IC50	Pharmacol Res (2016) 113: 18-37 [PMID:27521834]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]