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ChEMBL ligand: CHEMBL439259 (TCMDC-125497) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Inhibition of recombinant IGF1R by ELISA | B | 4.73 | pIC50 | 18700 | nM | IC50 | Bioorg Med Chem (2010) 18: 5995-6005 [PMID:20643554] |
ChEMBL | Inhibition of IGF1R-dependent tumor cell growth in human MCNeuA cells | B | 4.82 | pIC50 | 15000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of IGF1R autophosphorylation in human MCF7 cells | B | 4.92 | pIC50 | 12000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of IGF1R autophosphorylation in human MCF7 cells by ELISA | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2009) 52: 4981-5004 [PMID:19610618] |
ChEMBL | Inhibition of IGF1R-dependent tumor cell growth in human MCF7 cells | B | 5.1 | pIC50 | 8000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
GtoPdb | - | - | 6 | pIC50 | <1000 | nM | IC50 | Mol Cancer Ther (2006) 5: 1079-86 [PMID:16648580] |
ChEMBL | Inhibition of IGF1R autophosphorylation in human MCF7 cells by Western blot analysis | B | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (2009) 52: 4981-5004 [PMID:19610618] |
ChEMBL | Inhibition of IGF1R autophosphorylation | B | 6 | pIC50 | <1000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-sensetive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 72 hrs | F | 7.28 | pEC50 | 53 | nM | EC50 | ACS Med Chem Lett (2010) 1: 460-465 [PMID:21243104] |
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 72 hrs | F | 6.41 | pEC50 | 390 | nM | EC50 | ACS Med Chem Lett (2010) 1: 460-465 [PMID:21243104] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]