bumetanide [Ligand Id: 4837] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1072 (Betinex, Bumetanide, Bumex, Burinex, Lixil, RO 10-6338, RO-10-6338, RO-106338, S-95008., S95008.)
  • Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
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  • GPR35 in Human [GtoPdb: 102] [UniProtKB: Q9HC97]
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  • Kidney-specific Na-K-Cl symporter in Human [GtoPdb: 968] [UniProtKB: Q13621]
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  • Basolateral Na-K-Cl symporter in Human [GtoPdb: 969] [UniProtKB: P55011]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
ChEMBL TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes F 5.26 pKi 5500 nM Ki J Pharmacol Exp Ther (2000) 295: 261-265 [PMID:10991988]
GPR35 in Human [GtoPdb: 102] [UniProtKB: Q9HC97]
GtoPdb - - 5.54 pEC50 - - - Pharmacology (2012) 89: 13-7 [PMID:22236570]
Kidney-specific Na-K-Cl symporter in Human [GtoPdb: 968] [UniProtKB: Q13621]
GtoPdb - - 6.48 pIC50 - - - Naunyn Schmiedebergs Arch Pharmacol (2002) 365: 193-9 [PMID:11882915]
Basolateral Na-K-Cl symporter in Human [GtoPdb: 969] [UniProtKB: P55011]
GtoPdb - - 5.6 pIC50 - - - Naunyn Schmiedebergs Arch Pharmacol (2002) 365: 193-9 [PMID:11882915]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]