didanosine [Ligand Id: 4833] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1460 (BMY-40900, Ddi, (-)-didanosine, Didanosine, Didanosine system suitability mixture, Didanosinum, Dideoxyinosine (ddi), NSC-612049, Videx, Videx ec) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Inhibitory concentration against SO561945 (HIV 1 mutant RT) viral infection of MT-4 cells | F | 5.15 | pIC50 | 7150 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 3173-3176 [PMID:15149669] |
| ChEMBL | Concentration required to protect the cell against HIV-1 strain IIIB viral cytopathogenicity by 50% in MT-4 cells | F | 5.27 | pIC50 | 5370 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 3173-3176 [PMID:15149669] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
