vigabatrin [Ligand Id: 4821] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL89598 (5-hexenoic acid, 4-amino-, CPP-109, Gamma vinyl gaba, Gamma-vinyl gaba, MDL 71,754, MDL-71754, RMI-71754, Sabril, Vigabatrin, Vinyl gamma-aminobutyric acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404] | ||||||||
| GtoPdb | - | - | 3.07 | pKi | 850000 | nM | Ki |
Eur J Biochem (1977) 74: 441-5 [PMID:856582]; J Med Chem (2012) 55: 567-75 [PMID:22168767] |
| 4-aminobutyrate aminotransferase/4-aminobutyrate aminotransferase, mitochondrial in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523258] [GtoPdb: 2464] [UniProtKB: P61922] | ||||||||
| ChEMBL | Inhibition of GABA aminotransferase in mouse brain homogenates using GABA and alpha-ketoglutarate as substrates preincubated for 30 mins followed by beta-NADP addition and measured for 20 mins by spectrophotometric method | B | 4.4 | pIC50 | 39720 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1825-1830 [PMID:31084949] |
| 4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404] | ||||||||
| GtoPdb | - | - | 3.07 | pKi | 850000 | nM | Ki |
Eur J Biochem (1977) 74: 441-5 [PMID:856582]; J Med Chem (2012) 55: 567-75 [PMID:22168767] |
| 4-aminobutyrate aminotransferase/Gamma-amino-N-butyrate transaminase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3148] [GtoPdb: 2464] [UniProtKB: P50554] | ||||||||
| ChEMBL | Inhibition of Rattus norvegicus (rat) brain gamma-amino butyrate aminotransferase using gamma-amino butyrate as substrate assessed as decrease in NADPH generation after 30 min by spectrophotometric analysis | B | 4.38 | pIC50 | 41210 | nM | IC50 | Med Chem Res (2013) 22: 134-146 |
| Vesicular inhibitory amino acid transporter in Human [GtoPdb: 1133] [UniProtKB: Q9H598] | ||||||||
| GtoPdb | - | - | 2.1 | pIC50 | 7500000 | nM | IC50 | Nature (1997) 389: 870-6 [PMID:9349821] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
