ChEMBL ligand: CHEMBL640 (Novocainamide, NSC-27461, Procainamide, Procan, Procanbid, Procapan, Pronestyl, Pronestyl-SR, Sp 100 (pharmaceutical))
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] Acetylcholinesterase in Bovine [ChEMBL: CHEMBL4768] [UniProtKB: P23795] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966] Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2] There should be some charts here, you may need to enable JavaScript!
TAS2R9 in Human [GtoPdb: 665] [UniProtKB: Q9NYW1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Binding affinity against Acetylcholinesterase of human RBC	B	6	pKi	1000	nM	Ki	J Med Chem (1997) 40: 3009-3013 [PMID:9301662]
ChEMBL	Binding affinity against Acetylcholinesterase of purified Octopus brain (OB)	B	6	pKi	1000	nM	Ki	J Med Chem (1997) 40: 3009-3013 [PMID:9301662]
ChEMBL	Inhibition of Acetylcholinesterase from human red blood cells	B	6	pIC50	1000	nM	IC50	J Med Chem (1997) 40: 3009-3013 [PMID:9301662]
ChEMBL	Inhibition of Acetylcholinesterase activity from octopus brain	B	6	pIC50	1000	nM	IC50	J Med Chem (1997) 40: 3009-3013 [PMID:9301662]
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
ChEMBL	Binding affinity against Acetylcholinesterase of purified calf forebrain (CFB)	B	6	pKi	1000	nM	Ki	J Med Chem (1997) 40: 3009-3013 [PMID:9301662]
ChEMBL	Inhibition of Acetylcholinesterase activity of calf forebrain	B	6.3	pIC50	500	nM	IC50	J Med Chem (1997) 40: 3009-3013 [PMID:9301662]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells	F	4.13	pKi	73900	nM	Ki	J Pharmacol Exp Ther (1998) 286: 354-361 [PMID:9655880]
Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	F	5.41	pIC50	3900	nM	IC50	Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells	F	4.33	pKi	47000	nM	Ki	Pharm Res (2001) 18: 1528-1534 [PMID:11758759]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes	F	4.89	pKi	13000	nM	Ki	Nature (1994) 372: 549-552 [PMID:7990927]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells	F	4.92	pIC50	12000	nM	IC50	J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
ChEMBL	TP_TRANSPORTER: inhibition pramipexole uptake in rOCT1-injected oocytes	F	5.11	pIC50	7700	nM	IC50	Drug Metab Dispos (2005) 33: 495-499 [PMID:15640376]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells	F	5.15	pIC50	7000	nM	IC50	J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes	F	4.3	pKi	50000	nM	Ki	DNA Cell Biol (1997) 16: 871-881 [PMID:9260930]
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells	F	4.44	pKi	36000	nM	Ki	Pharm Res (2001) 18: 1528-1534 [PMID:11758759]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells	F	4.05	pIC50	90000	nM	IC50	J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
TAS2R9 in Human [GtoPdb: 665] [UniProtKB: Q9NYW1]
GtoPdb	-	-	2.55	pEC50	2800000	nM	EC50	PLoS One (2008) 3: e3974 [PMID:19092995]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]