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ChEMBL ligand: CHEMBL1090 (ARA-A, Arabinosyladenine, Arasena-a, CI 673, CI-673, NSC-247519, NSC-404241, NSC-757383, Vidarabine, Vidarabine anhydrous, Vidarabine, anhydrous, Vidarabine monohydrate, Vira-a) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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S-Adenosylhomocysteine hydrolase/Adenosylhomocysteinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2389] [GtoPdb: 1233] [UniProtKB: P50247] | ||||||||
ChEMBL | Activity determined in mouse liver S-adenosyl-L-homocysteine hydrolase and expressed as KI values. | B | 4.52 | pKi | 30000 | nM | Ki | J Med Chem (1991) 34: 647-656 [PMID:1995889] |
adenylyl cyclase 5/Adenylate cyclase type V in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2880] [GtoPdb: 1282] [UniProtKB: Q04400] | ||||||||
ChEMBL | Compound was evaluated for inhibition of adenylate cyclase from rat brain | B | 4.09 | pIC50 | 82000 | nM | IC50 | J Med Chem (2004) 47: 1207-1213 [PMID:14971900] |
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
ChEMBL | Inhibition of human DPP4 from human Caco-2 cells | B | 7.21 | pIC50 | 62 | nM | IC50 | J Med Chem (2010) 53: 559-572 [PMID:20000418] |
Hepatitis C virus NS5B RNA-dependent RNA polymerase in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5375] [UniProtKB: Q8JXU8] | ||||||||
ChEMBL | Inhibition HCV NS5B-mediated RNA synthesis | F | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2004) 47: 2283-2295 [PMID:15084127] |
ChEMBL | Inhibition HCV RNA replication | F | 4.3 | pEC50 | >50000 | nM | EC50 | J Med Chem (2004) 47: 2283-2295 [PMID:15084127] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]