L-tyrosine [Ligand Id: 4791] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL925 (FEMA NO. 3736, Levodopa impurity, l-tyrosine-, Levodopa related compound l-tyrosine, L-tyrosine, NSC-82624, Tyrosine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| L-type amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650] | ||||||||
| ChEMBL | Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH | B | 4.17 | pIC50 | 68000 | nM | IC50 | J Med Chem (2018) 61: 7358-7373 [PMID:30048132] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
