L-tyrosine [Ligand Id: 4791] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL925 (FEMA NO. 3736, Levodopa impurity, l-tyrosine-, Levodopa related compound l-tyrosine, L-tyrosine, NSC-82624, Tyrosine)
  • L-type amino acid transporter 1 in Human [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
L-type amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650]
ChEMBL Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH B 4.17 pIC50 68000 nM IC50 J Med Chem (2018) 61: 7358-7373 [PMID:30048132]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]