zebularine [Ligand Id: 4729] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL504567 (Zebularine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| Adenosine deaminase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3206] [GtoPdb: 1230] [UniProtKB: P03958] | ||||||||
| ChEMBL | Compound was tested for the inhibitory constant for adenosine deaminase (ADA) | B | 6 | pKi | 1000 | nM | Ki | J Med Chem (1986) 29: 1374-1380 [PMID:3735306] |
| cytidine deaminase/Cytidine deaminase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4502] [GtoPdb: 3133] [UniProtKB: P32320] | ||||||||
| ChEMBL | Compound was tested for its binding affinity against cytidine deaminase. | B | 4.42 | pKi | 38000 | nM | Ki | J Med Chem (1998) 41: 2572-2578 [PMID:9651161] |
| ChEMBL | Apparent Ki (binding affinity) was calculated for the compound against cytidine deaminase. | B | 5.64 | pKi | 2300 | nM | Ki | J Med Chem (1998) 41: 2572-2578 [PMID:9651161] |
| ChEMBL | Binding affinity for human cytidine deaminase | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (2005) 48: 658-660 [PMID:15689149] |
| Cytidine deaminase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2110] [UniProtKB: P56389] | ||||||||
| ChEMBL | Compound was tested for the inhibitory constant for mouse kidney cytidine deaminase | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (1986) 29: 1374-1380 [PMID:3735306] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
