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ChEMBL ligand: CHEMBL52609 (2'deoxythymidine, 2'-deoxythymidine, Deoxyribothymidine, Doxribtimine, MT1621 (dT), NSC-21548, Thymidin, Thymidine, Thymidinedeoxyriboside, Thymine-2-desoxyriboside, Zidovudine related compound d, Zidovudine related compound d rs) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ATPase family AAA domain containing 2/ATPase family AAA domain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150837] [GtoPdb: 2719] [UniProtKB: Q6PL18] | ||||||||
ChEMBL | Binding affinity to recombinant human ATAD2 (982 to 1108 amino acids) bromodomain radiolabelled at methyl groups of leucine, valine, isoleucine, methionine expressed in Escherichia coli BL21 (DE3) by NMR titration | B | 2 | pKd | 10000000 | nM | Kd | Medchemcomm (2014) 5: 1843-1848 |
Thymidine kinase in Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1820] [UniProtKB: P06479] | ||||||||
ChEMBL | Binding affinity towards HSV-1 thymidine kinase | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (1996) 39: 4727-4737 [PMID:8941385] |
Thymidine kinase in Macacine herpesvirus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075062] [UniProtKB: A3RLP8] | ||||||||
ChEMBL | Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation | B | 5.39 | pIC50 | 4100 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 2028-2034 [PMID:17438061] |
Thymidine kinase, cytosolic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2883] [UniProtKB: P04183] | ||||||||
ChEMBL | Inhibition of HSV-1 thymidine kinase | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (1992) 35: 4214-4220 [PMID:1331461] |
ChEMBL | Binding affinity constant against HSV-1 thymidine kinase | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2003) 46: 5045-5054 [PMID:14584954] |
ChEMBL | Inhibitory concentration against HSV-1 TK (WT) catalyzed [3H]-GCV phosphorylation | F | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2002) 45: 4254-4263 [PMID:12213066] |
ChEMBL | Inhibitory activity (50 uM) against HSV-1 Thymidine kinase in OST-TK-/HSV-1 TK+ cell line in combination with gancicclovir | B | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2002) 45: 4254-4263 [PMID:12213066] |
ChEMBL | Inhibitory activity (50 uM) against HSV-1 Thymidine kinase in OST-TK-/HSV-1 TK+ cell line in combination with BVAraU | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2002) 45: 4254-4263 [PMID:12213066] |
Thymidylate kinase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2361] [UniProtKB: P9WKE1] | ||||||||
ChEMBL | Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis | B | 4.57 | pKi | 27000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 3045-3048 [PMID:12941330] |
ChEMBL | In Vitro inhibition of Thymidine Monophosphatase Kinase of Mycobacterium tuberculosis (TMPKm) | B | 4.57 | pKi | 27000 | nM | Ki | J Med Chem (2003) 46: 3811-3821 [PMID:12930144] |
ChEMBL | Binding affinity towards mycobacterium tuberculosis thymidine monophosphate kinase | B | 4.57 | pKi | 27000 | nM | Ki | J Med Chem (2005) 48: 2457-2468 [PMID:15801836] |
ChEMBL | Inhibition of Mycobacterium tuberculosis TMPK by coupled spectrophotometric assay | B | 4.57 | pKi | 27000 | nM | Ki | J Med Chem (2004) 47: 6187-6194 [PMID:15566289] |
ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant TMPK | B | 4.57 | pKi | 27000 | nM | Ki | Bioorg Med Chem (2008) 16: 6075-6085 [PMID:18467107] |
ChEMBL | Inhibition of Mycobacterium tuberculosis TMPK using dTMP substrate and NADH by pyruvate kinase/lactate dehydrogenase coupling system based spectrophotometric assay | B | 4.57 | pKi | 27000 | nM | Ki | US-20080096907-A1. Aryl, Pyrimidyl Compounds, Pharmaceutical Compositions Comprising them, Their Use as Antimicrobial Agents (2008) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]