[3H]folic acid [Ligand Id: 4562] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1622 (Acidum folicum, B03BB01, Bio science, Folacin, Folate, Foldine, Folettes, Foliamin, Folic acid, Folic Acid, Folicare, Folicet, Folipac, Folsan, Folvite, Incafolic, Lexpec, Millafol, Natur flow, NSC-3073, Preconceive, Pteroylglutamic acid, Roche, Vitamin b9, Vitamin bc, Vitamin Bc, Vitamin m, Vitamin M) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| ChEMBL | Inhibition of recombinant human ALR2 using D,L-glyceraldehyde and NADPH as substrate preincubated for 3 mins followed by substrate addition and measured for 3 mins by spectrophotometric analysis | B | 4.28 | pIC50 | 52500 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 4870-4874 [PMID:27666634] |
| Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4] | ||||||||
| ChEMBL | Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 5.32 | pKd | 4800 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| ChEMBL | Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 5.36 | pKd | 4400 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| ChEMBL | Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 6.09 | pKd | 810 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells | F | 4.85 | pKi | 14100 | nM | Ki | J Pharmacol Exp Ther (2000) 293: 1034-1039 [PMID:10869408] |
| thymidylate synthetase/Thymidylate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1952] [GtoPdb: 2642] [UniProtKB: P04818] | ||||||||
| ChEMBL | Inhibitory constant of thymidylate synthase was determined in human AML cells | B | 4.4 | pKi | 40000 | nM | Ki | J Med Chem (1987) 30: 675-678 [PMID:3470522] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
