[3H]folic acid [Ligand Id: 4562] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1622 (Acidum folicum, B03BB01, Bio science, Folacin, Folate, Foldine, Folettes, Foliamin, Folic acid, Folic Acid, Folicare, Folicet, Folipac, Folsan, Folvite, Incafolic, Lexpec, Millafol, Natur flow, NSC-3073, Preconceive, Pteroylglutamic acid, Roche, Vitamin b9, Vitamin bc, Vitamin Bc, Vitamin m, Vitamin M) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| ChEMBL | Inhibition of recombinant human ALR2 using D,L-glyceraldehyde and NADPH as substrate preincubated for 3 mins followed by substrate addition and measured for 3 mins by spectrophotometric analysis | B | 4.28 | pIC50 | 52500 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 4870-4874 [PMID:27666634] |
| Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4] | ||||||||
| ChEMBL | Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 5.32 | pKd | 4800 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| ChEMBL | Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 5.36 | pKd | 4400 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| ChEMBL | Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 | B | 6.09 | pKd | 810 | nM | Kd | J Med Chem (1988) 31: 129-137 [PMID:3275776] |
| Solute carrier organic anion transporter family member 1A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073707] [UniProtKB: P70502] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells | F | 4.85 | pKi | 14100 | nM | Ki | J Pharmacol Exp Ther (2000) 293: 1034-1039 [PMID:10869408] |
| thymidylate synthetase/Thymidylate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1952] [GtoPdb: 2642] [UniProtKB: P04818] | ||||||||
| ChEMBL | Inhibitory constant of thymidylate synthase was determined in human AML cells | B | 4.4 | pKi | 40000 | nM | Ki | J Med Chem (1987) 30: 675-678 [PMID:3470522] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
