hypoxanthine [Ligand Id: 4555] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1427 (Hypoxanthine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Inhibition of [3H]hypoxanthine uptake in Plasmodium falciparum 3D7 | F | 5.38 | pIC50 | 4200 | nM | IC50 | J Med Chem (2006) 49: 7479-7486 [PMID:17149876] |
| Purine nucleoside phosphorylase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2935] [UniProtKB: P55859] | ||||||||
| ChEMBL | Binding affinity to calf recombinant PNP Phe200Trp mutant expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis | B | 5.9 | pKd | 1250 | nM | Kd | Bioorg Med Chem (2012) 20: 6758-6769 [PMID:23040896] |
| ChEMBL | Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry | B | 6.17 | pKd | 680 | nM | Kd | Bioorg Med Chem (2012) 20: 6758-6769 [PMID:23040896] |
| purine nucleoside phosphorylase/Purine-nucleoside phosphorylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2395] [GtoPdb: 2841] [UniProtKB: P85973] | ||||||||
| ChEMBL | Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) | B | 4.77 | pKi | 17000 | nM | Ki | J Med Chem (1994) 37: 2477-2480 [PMID:8057293] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
