creatine [Ligand Id: 4496] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL283800 (Cosmocair c 100, Creatine, Kreatinum, Neotine, NSC-8752) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8] | ||||||||
| ChEMBL | Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting | B | 0.51 | pKi | -0.51 | mM | pKi | Bioorg Med Chem (2011) 19: 6409-6418 [PMID:21955456] |
| CT1/Sodium- and chloride-dependent creatine transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5209634] [GtoPdb: 934] [UniProtKB: P48029] | ||||||||
| ChEMBL | Substrate uptake by the Sodium- and Chloride-Dependent Creatine Transporter 1 (CRTR, SLC6A8) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A8 cells (PubChem AID: 1794823) | F | 5.3 | pEC50 | 5000 | nM | EC50 | Membrane potential based assay for SLC6A8 using HEK-293 JumpIN SLC6A8 OE cells |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
