hemicholinium-3 [Ligand Id: 4494] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL268697 (HC-3, hemicholinium-3)
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  • CHT in Human [GtoPdb: 914] [UniProtKB: Q9GZV3]
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  • Choline transporter-like 1 in Human [GtoPdb: 1204] [UniProtKB: Q8WWI5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by picogreen-microfluorimetric assay F 4.3 pIC50 >50000 nM IC50 Bioorg Med Chem Lett (2018) 28: 2485-2489 [PMID:29880399]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorimetric assay F 4.3 pIC50 >50000 nM IC50 Bioorg Med Chem Lett (2018) 28: 2485-2489 [PMID:29880399]
CHT in Human [GtoPdb: 914] [UniProtKB: Q9GZV3]
GtoPdb - - 8 pKi 10 nM Ki Neurochem Res (2003) 28: 483-8 [PMID:12675135]
Choline transporter-like 1 in Human [GtoPdb: 1204] [UniProtKB: Q8WWI5]
GtoPdb - - 4.5 pKi 31000 nM Ki

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]