RO3 [Ligand Id: 4298] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL494772
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2X3/P2X2/P2X2/P2X3 heterotrimeric receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3831281] [GtoPdb: 480, 479] [UniProtKB: P56373, Q9UBL9]
ChEMBL Antagonist activity at human recombinant P2X2/3 receptor expressed in human 1321N1 cells by FLIPR assay F 5.7 pIC50 1995.26 nM IC50 Bioorg Med Chem Lett (2009) 19: 1628-1631 [PMID:19231180]
GtoPdb - - 7.5 pIC50 ~31 nM IC50 Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177]
P2X3 in Human [GtoPdb: 480] [UniProtKB: P56373]
GtoPdb - - 7.5 pIC50 ~31 nM IC50 Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177]
P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654]
ChEMBL Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assay F 6.9 pIC50 125.89 nM IC50 Bioorg Med Chem Lett (2009) 19: 1628-1631 [PMID:19231180]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]