flunitrazepam [Ligand Id: 4193] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL13280 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GABAA receptor α1 subunit in Human [GtoPdb: 404] [UniProtKB: P14867] | ||||||||
| GtoPdb | Assay using recombinant GABAA channels with subunit composition; α1β3γ2. | - | 8.28 | pKi | 5.2 | nM | Ki | Mol Pharmacol (1996) 49: 253-9 [PMID:8632757] |
| GABAA receptor α2 subunit in Human [GtoPdb: 405] [UniProtKB: P47869] | ||||||||
| GtoPdb | Assay using recombinant GABAA channels with subunit composition; α2β1γ2. | - | 8.28 | pKi | 5.2 | nM | Ki | Mol Pharmacol (1996) 49: 253-9 [PMID:8632757] |
| GABAA receptor α3 subunit in Human [GtoPdb: 406] [UniProtKB: P34903] | ||||||||
| GtoPdb | Assay using recombinant GABAA channels with subunit composition; α3β1γ2. | - | 7.8 | pKi | 15.7 | nM | Ki | Mol Pharmacol (1996) 49: 253-9 [PMID:8632757] |
| GABAA receptor α5 subunit in Human [GtoPdb: 408] [UniProtKB: P31644] | ||||||||
| GtoPdb | Assay using recombinant GABAA channels with subunit composition; α5β1γ2. | - | 8.26 | pKi | 5.5 | nM | Ki | Mol Pharmacol (1996) 49: 253-9 [PMID:8632757] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
