BAYu9773 [Ligand Id: 3381] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL285954 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271] | ||||||||
| GtoPdb | - | - | 5.3 | pIC50 | 5000 | nM | IC50 | Br J Pharmacol (2010) 160: 399-409 [PMID:20423349] |
| GtoPdb | - | - | 6.36 | pIC50 | 440 | nM | IC50 | Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
| CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75] | ||||||||
| GtoPdb | - | - | 5.34 | pIC50 | 4600 | nM | IC50 | J Pharmacol Exp Ther (2011) 339: 768-78 [PMID:21903747] |
| GtoPdb | - | - | 6.4 | pIC50 | 400 | nM | IC50 |
J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]; Br J Pharmacol (2010) 160: 399-409 [PMID:20423349] |
| GtoPdb | - | - | 6.52 | pIC50 | 300 | nM | IC50 | Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
| GtoPdb | - | - | 7.74 | pIC50 | 18 | nM | IC50 | Br J Pharmacol (2010) 160: 399-409 [PMID:20423349] |
| GtoPdb | - | - | 7.04 | pEC50 | 92 | nM | EC50 | Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
| GtoPdb | - | - | 7.16 | pEC50 | 69 | nM | EC50 | Br J Pharmacol (2010) 160: 399-409 [PMID:20423349] |
| CysLT2 receptor in Rat [GtoPdb: 270] [UniProtKB: Q924T9] | ||||||||
| GtoPdb | against LTC4 and LTD4 induced contraction in smooth muscle preparation | - | 7.7 | pA2 | - | - | - | Eur J Pharmacol (1994) 264: 317-323 [PMID:7698171] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
