ChEMBL ligand: CHEMBL285954
CysLT1 receptor/Cysteinyl leukotriene receptor 1 in Human [ChEMBL: CHEMBL1798] [GtoPdb: 269] [UniProtKB: Q9Y271] Cysteinyl leukotriene receptor 1 in Guinea pig [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5] There should be some charts here, you may need to enable JavaScript!
CysLT2 receptor/Cysteinyl leukotriene receptor 2 in Human [ChEMBL: CHEMBL4330] [GtoPdb: 270] [UniProtKB: Q9NS75] CysLT2 receptor in Rat [GtoPdb: 270] [UniProtKB: Q924T9] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CysLT1 receptor/Cysteinyl leukotriene receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1798] [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb	-	-	5.3	pIC50	5000	nM	IC50	Br J Pharmacol (2010) 160: 399-409 [PMID:20423349]
ChEMBL	Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay	F	6.36	pIC50	440	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 1230-1234 [PMID:25408836]
GtoPdb	-	-	6.36	pIC50	440	nM	IC50	Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
Cysteinyl leukotriene receptor 1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5]
ChEMBL	Compound was evaluated for its binding affinity on guinea-pig ileum	B	7	pKi	100	nM	Ki	Bioorg. Med. Chem. Lett. (1993) 3: 1517-1522
CysLT2 receptor/Cysteinyl leukotriene receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4330] [GtoPdb: 270] [UniProtKB: Q9NS75]
GtoPdb	-	-	5.34	pIC50	4600	nM	IC50	J Pharmacol Exp Ther (2011) 339: 768-78 [PMID:21903747]
GtoPdb	-	-	6.4	pIC50	400	nM	IC50	J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]; Br J Pharmacol (2010) 160: 399-409 [PMID:20423349]
GtoPdb	-	-	6.52	pIC50	300	nM	IC50	Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
ChEMBL	Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay	F	6.52	pIC50	300	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 1230-1234 [PMID:25408836]
GtoPdb	-	-	7.74	pIC50	18	nM	IC50	Br J Pharmacol (2010) 160: 399-409 [PMID:20423349]
GtoPdb	-	-	7.04	pEC50	92	nM	EC50	Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
GtoPdb	-	-	7.16	pEC50	69	nM	EC50	Br J Pharmacol (2010) 160: 399-409 [PMID:20423349]
CysLT2 receptor in Rat [GtoPdb: 270] [UniProtKB: Q924T9]
GtoPdb	against LTC4 and LTD4 induced contraction in smooth muscle preparation	-	7.7	pA2	-	-	-	Eur J Pharmacol (1994) 264: 317-323 [PMID:7698171]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]