pobilukast [Ligand Id: 3334] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL22776 (Pobilukast, SKF-104353) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CysLT1 receptor/Cysteinyl leukotriene receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1798] [GtoPdb: 269] [UniProtKB: Q9Y271] | ||||||||
| GtoPdb | against [3H]LTD4 in human lung parenchyma | - | 7.1 | pKi | - | - | - | Mol Pharmacol (1998) 53: 750-8 [PMID:9547367] |
| ChEMBL | Binding affinity against Cysteinyl leukotriene D4 receptor in human lung membranes using [3H]LTD4 as the radioligand. | B | 8 | pKi | 10 | nM | Ki | J Med Chem (1987) 30: 959-961 [PMID:3035179] |
| GtoPdb | - | - | 7.52 | pIC50 | 30 | nM | IC50 | Mol Pharmacol (1999) 56: 657-63 [PMID:10462554] |
| GtoPdb | - | - | 8.26 | pIC50 | 5.5 | nM | IC50 | Mol Pharmacol (1999) 56: 657-63 [PMID:10462554] |
| Cysteinyl leukotriene receptor 1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5645] [UniProtKB: Q2NNR5] | ||||||||
| ChEMBL | Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranes. | B | 8.3 | pKi | 5 | nM | Ki | J Med Chem (1990) 33: 1781-1790 [PMID:2342072] |
| ChEMBL | Compound was evaluated for its ability to displace [3H]LTD4 from LTD4 receptor in guinea pig lung membranes | B | 8.3 | pKi | 5 | nM | Ki | J Med Chem (1991) 34: 1235-1242 [PMID:1849993] |
| ChEMBL | Binding affinity against Cysteinyl leukotriene D4 receptor in guinea pig lung membranes using [3H]LTD4 as the radioligand. | B | 8.3 | pKi | 5 | nM | Ki | J Med Chem (1987) 30: 959-961 [PMID:3035179] |
| CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75] | ||||||||
| GtoPdb | against LTC4 Ca2+ mobilisation assay in HUVEC | - | 6.2 | pA2 | - | - | - | Prostaglandins Other Lipid Mediat (2015) 120: 115-25 [PMID:25839425] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
