ChEMBL ligand: CHEMBL301523 (FEMA NO. 3585, Laevo-phenyl alanine, L-phenylalanine, NSC-79477, Phenylalanine)
Alkaline phosphatase, tissue-nonspecific isozyme in Human [ChEMBL: CHEMBL5979] [UniProtKB: P05186] There should be some charts here, you may need to enable JavaScript!
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] There should be some charts here, you may need to enable JavaScript!
Intestinal alkaline phosphatase in Human [ChEMBL: CHEMBL5573] [UniProtKB: P09923] Intestinal alkaline phosphatase in Bovine [ChEMBL: CHEMBL5695] [UniProtKB: P19111] There should be some charts here, you may need to enable JavaScript!
L-type amino acid transporter 1 in Human [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650] L-type amino acid transporter 1 in Rat [ChEMBL: CHEMBL4149] [GtoPdb: 896] [UniProtKB: Q63016] There should be some charts here, you may need to enable JavaScript!
Phospholipase A-2-activating protein in Human [ChEMBL: CHEMBL6114] [UniProtKB: Q9Y263] There should be some charts here, you may need to enable JavaScript!
Voltage-gated calcium channel alpha2/delta subunit 1 in Mouse [ChEMBL: CHEMBL4676] [UniProtKB: O08532] There should be some charts here, you may need to enable JavaScript!
GPR139 in Human [GtoPdb: 130] [UniProtKB: Q6DWJ6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Alkaline phosphatase, tissue-nonspecific isozyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5979] [UniProtKB: P05186]
ChEMBL	Inhibition of TNAP by analogous luminescence assay	B	5.3	pIC50	>5000	nM	IC50	Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL	Inhibition of human IAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured after 20 mins by luminescence-based assay	B	4.1	pIC50	80200	nM	IC50	Eur J Med Chem (2018) 156: 461-478 [PMID:30015078]
Intestinal alkaline phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5573] [UniProtKB: P09923]
ChEMBL	Inhibition of human IAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by substrate addition and measured after 15 to 20 mins by spectrophotometric method	B	4	pIC50	100000	nM	IC50	Eur J Med Chem (2018) 159: 282-291 [PMID:30296687]
ChEMBL	Inhibition of IAP by analogous luminescence assay	B	5.3	pIC50	>5000	nM	IC50	Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422]
Intestinal alkaline phosphatase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5695] [UniProtKB: P19111]
ChEMBL	Inhibition of calf intestinal alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric method	B	4.1	pIC50	80210	nM	IC50	Bioorg Med Chem (2015) 23: 2435-2444 [PMID:25865133]
ChEMBL	Inhibition of calf intestinal alkaline phosphatase using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectrophotometric method	B	4.1	pIC50	80210	nM	IC50	Eur J Med Chem (2017) 126: 408-420 [PMID:27907877]
L-type amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650]
ChEMBL	Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH	B	4.16	pIC50	69000	nM	IC50	J Med Chem (2018) 61: 7358-7373 [PMID:30048132]
ChEMBL	Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis	B	4.16	pIC50	69000	nM	IC50	Bioorg Med Chem Lett (2019) 29: 2254-2258 [PMID:31248771]
L-type amino acid transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4149] [GtoPdb: 896] [UniProtKB: Q63016]
ChEMBL	Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation counting	B	4.26	pKi	55000	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3688-3691 [PMID:20466543]
Phospholipase A-2-activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6114] [UniProtKB: Q9Y263]
ChEMBL	Inhibition of PLAP by analogous luminescence assay	B	5.3	pIC50	>5000	nM	IC50	Bioorg Med Chem (2010) 18: 573-579 [PMID:20031422]
Voltage-gated calcium channel alpha2/delta subunit 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4676] [UniProtKB: O08532]
ChEMBL	Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brain	B	6.01	pKi	980	nM	Ki	Bioorg Med Chem Lett (2006) 16: 1138-1141 [PMID:16380257]
ChEMBL	Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brain	B	6.01	pKi	977.24	nM	Ki	Bioorg Med Chem Lett (2006) 16: 1138-1141 [PMID:16380257]
GPR139 in Human [GtoPdb: 130] [UniProtKB: Q6DWJ6]
GtoPdb	Inhibition equilibrium constant from a radioligand membrane binding assay.	-	3.06	pKi	872000	nM	Ki	Mol Pharmacol (2015) 88: 911-25 [PMID:26349500]
GtoPdb	Measured using a GTPγS assay in transfected COS7 cells.	-	4.51	pIC50	31000	nM	IC50	Mol Pharmacol (2015) 88: 911-25 [PMID:26349500]
GtoPdb	-	-	3.49	pEC50	320000	nM	EC50	J Chem Inf Model (2014) 54: 1553-7 [PMID:24826842]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]