BPH-628 [Ligand Id: 3188] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL262616 ((1-Hydroxy-1-Phosphono-2-[1,1';4',1'']Terphenyl-3-Yl-Ethyl)-Phosphonic Acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| Geranylgeranyl pyrophosphate synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075251] [UniProtKB: Q12051] | ||||||||
| ChEMBL | Binding affinity to Saccharomyces cerevisiae GGPPS | B | 7.52 | pKi | 30 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
| ChEMBL | Inhibition of Saccharomyces cerevisiae GGPPS | B | 7.15 | pIC50 | 70 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
| geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] | ||||||||
| ChEMBL | Binding affinity to human GGPPS | B | 7.7 | pKi | 20 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
| ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 6.1 | pIC50 | 794.33 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
| GtoPdb | Inhibition of human GGPPS; radiometric assay | - | 6.14 | pIC50 | 720 | nM | IC50 | Proc Natl Acad Sci USA (2007) 104: 10022-7 [PMID:17535895] |
| GtoPdb | Inhibition of human recombinant geranylgeranyl diphosphate synthase | - | 6.14 | pIC50 | 720 | nM | IC50 | J Med Chem (2008) 51: 5594-607 [PMID:18800762] |
| ChEMBL | Inhibition of human GGPPS | B | 6.14 | pIC50 | 720 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 10022-10027 [PMID:17535895] |
| ChEMBL | Inhibition of human recombinant geranylgeranyl diphosphate synthase | B | 6.14 | pIC50 | 720 | nM | IC50 | J Med Chem (2008) 51: 5594-5607 [PMID:18800762] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
