NE11808 [Ligand Id: 3160] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL294192 (NE11808)
  • farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
Created with Highcharts 10.3.3ValuesChart context menuFarnesyl diphosphate synthasepKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
Created with Highcharts 10.3.3ValuesChart context menuFarnesyl pyrophosphate synthasepKd Leishmania donovanipKi Leishmania donovanipIC50 Leishmania donovanipEC50 Leishmania donovani02468Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium falciparumpKd Plasmodium falciparumpKi Plasmodium falciparumpIC50 Plasmodium falciparumpEC50 Plasmodium falciparum0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
GtoPdb Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins - 7.43 pKi 36.9 nM Ki J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 B 7.43 pKi 36.9 nM Ki J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand B 7.8 pKi 16 nM Ki J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins B 8.64 pKi 2.3 nM Ki J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins - 8.64 pKi 2.3 nM Ki J Med Chem (2008) 51: 2187-95 [PMID:18327899]
GtoPdb Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins - 6.72 pIC50 190.1 nM IC50 J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 B 6.72 pIC50 190.1 nM IC50 J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase was determined B 6.77 pIC50 170 nM IC50 J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) B 6.77 pIC50 169.82 nM IC50 J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
GtoPdb Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins - 7.82 pIC50 15 nM IC50 J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins B 7.82 pIC50 15 nM IC50 J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL Inhibitory activity against Leishmania major Farnesyl diphosphate synthase B 6.77 pIC50 170 nM IC50 J Med Chem (2004) 47: 175-187 [PMID:14695831]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Growth inhibition of Plasmodium falciparum F 4.55 pIC50 28000 nM IC50 J Med Chem (2008) 51: 7827-7833 [PMID:19053772]
ChEMBL Growth inhibition of Plasmodium falciparum F 4.6 pIC50 25118.86 nM IC50 J Med Chem (2008) 51: 7827-7833 [PMID:19053772]
ChEMBL In vitro growth inhibition against Plasmodium falciparum F 4.77 pIC50 17000 nM IC50 J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 4.77 pIC50 17000 nM IC50 Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]