compound 11 [PMID: 7473541] [Ligand Id: 3096] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL31608
  • Beta-1 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
There should be some charts here, you may need to enable JavaScript!
  • Beta-2 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
There should be some charts here, you may need to enable JavaScript!
  • squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
ChEMBL Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation B 6.5 pKd 316.23 nM Kd J Med Chem (1982) 25: 1408-1412 [PMID:6130154]
ChEMBL Activity at beta-1 adrenergic receptor B 6.5 pKd 316.23 nM Kd J Med Chem (1992) 35: 4676-4682 [PMID:1361581]
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
ChEMBL Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation B 6.1 pKd 794.33 nM Kd J Med Chem (1982) 25: 1408-1412 [PMID:6130154]
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
GtoPdb Inhibition of rat microsomal squalene synthase - 5.85 pIC50 1400 nM IC50 J Med Chem (1995) 38: 4157-60 [PMID:7473541]
ChEMBL Inhibition of rat microsomal squalene synthase B 5.85 pIC50 1400 nM IC50 J Med Chem (1995) 38: 4157-4160 [PMID:7473541]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]