ChEMBL ligand: CHEMBL280978
farnesyltransferase, CAAX box, subunit beta/farnesyltransferase, CAAX box, subunit alpha/Protein farnesyltransferase in Rat [ChEMBL: CHEMBL2095197] [GtoPdb: 2826, 2825] [UniProtKB: Q02293, Q04631] There should be some charts here, you may need to enable JavaScript!
squalene synthase /Squalene synthetase in Human [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyltransferase, CAAX box, subunit beta/farnesyltransferase, CAAX box, subunit alpha/Protein farnesyltransferase in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095197] [GtoPdb: 2826, 2825] [UniProtKB: Q02293, Q04631]
ChEMBL	Inhibition of Farnesyltransferase	B	7.92	pIC50	12	nM	IC50	J Med Chem (2002) 45: 1460-1465 [PMID:11906287]
squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268]
GtoPdb	Human enzyme expressed in yeast, in vitro assay	-	9.6	pKi	0.25	nM	Ki	Arch Biochem Biophys (1995) 316: 713-23 [PMID:7864626]
ChEMBL	In vitro inhibitory activity of compound was measured against Candida squalene synthase(SQS) enzyme	B	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (1993) 3: 2541-2546
ChEMBL	Inhibition of Candida albicans squalene synthase(SQS)	B	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (1993) 3: 2605-2610
GtoPdb	in vitro, soluable microsomal enzymes purified from rat and human liver microsomes	-	9.15	pIC50	0.7	nM	-	Arch Biochem Biophys (1998) 350: 283-90 [PMID:9473303]
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
GtoPdb	Compound was tested for inhibition of squalene synthase in rat liver.	-	10.11	pKi	0.08	nM	Ki	Proc Natl Acad Sci USA (1993) 90: 80-4 [PMID:8419946]
ChEMBL	In vitro inhibitory activity against Squalene synthase from rats	B	7.92	pIC50	12	nM	IC50	J Med Chem (1996) 39: 1413-1422 [PMID:8691471]
ChEMBL	In vitro inhibitory activity measured against rat squalene synthase(SQS) enzyme	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (1993) 3: 2541-2546
ChEMBL	Inhibitory concentration against mammalian Squalene synthase	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (1994) 4: 2683-2688
ChEMBL	In vitro inhibitory concentration against squalene synthase from male rat liver microsomes	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (1994) 4: 661-666
ChEMBL	Inhibition of rat liver squalene synthase(SQS)	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (1993) 3: 2605-2610
ChEMBL	In vitro inhibition of rat squalene synthase	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (1994) 4: 1931-1936
ChEMBL	Inhibition of rat liver squalene synthase by liqiud scintillation counting	B	9.3	pIC50	0.5	nM	IC50	J Nat Prod (1993) 56: 1923-1929 [PMID:8289063]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]