trans,trans-farnesyl diphosphate [Ligand Id: 3050] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL69330 (Farnesyl Diphosphate)
Created with Highcharts 10.3.3ValuesChart context menuFarnesyltransferasepKd Saccharomyces cerevisiae S288cpKi Saccharomyces cerevisiae S288cpIC50 Saccharomyces cerevisiae S288cpEC50 Saccharomyces cerevisiae S288c02468Highcharts.com
  • farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human [ChEMBL: CHEMBL2094108] [GtoPdb: 28252826] [UniProtKB: P49354P49356]
Created with Highcharts 10.3.3ValuesChart context menuProtein farnesyltransferasepKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
Created with Highcharts 10.3.3ValuesChart context menuSqualene synthetasepKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
  • mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
  • mevalonate kinase in Rat [GtoPdb: 640] [UniProtKB: P17256]
Created with Highcharts 10.3.3ValuesChart context menumevalonate kinasepKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Farnesyltransferase in Saccharomyces cerevisiae S288c (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111393] [UniProtKB: P22007P29703]
ChEMBL Inhibition of yeast Farnesyl transferase B 7.12 pKd 75 nM Kd Bioorg Med Chem Lett (1997) 7: 2125-2130
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094108] [GtoPdb: 28252826] [UniProtKB: P49354P49356]
ChEMBL Binding affinity to FTase (unknown origin) B 8.7 pKd 2 nM Kd Medchemcomm (2013) 4: 476-492 [PMID:25530833]
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
ChEMBL Inhibitory activity against microsomal Squalene synthase B 5.59 pKi 2600 nM Ki J Med Chem (1991) 34: 1912-1914 [PMID:2061928]
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426]
GtoPdb recombinant enzyme expressed in E coli cells. Spectrophotometric assay - 7 pKi 101 nM Ki J Lipid Res (1997) 38: 2216-23 [PMID:9392419]
GtoPdb recombinant wild type enzyme expressed in E coli, in vitro spectrophotometric assay - 7.47 pKi 34 nM Ki Biochemistry (2008) 47: 3715-24 [PMID:18302342]
mevalonate kinase in Rat [GtoPdb: 640] [UniProtKB: P17256]
GtoPdb in vitro, spectrophotometric assay - 5.6 pKi 2500 nM Ki J Biol Chem (1990) 265: 2391-8 [PMID:2153681]
GtoPdb spectrophotometric in vitro assay - 6.46 pKi 348 nM Ki J Bacteriol (2004) 186: 61-7 [PMID:14679225]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]