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ChEMBL ligand: CHEMBL69330 (Farnesyl Diphosphate) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Farnesyltransferase in Saccharomyces cerevisiae S288c (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111393] [UniProtKB: P22007, P29703] | ||||||||
ChEMBL | Inhibition of yeast Farnesyl transferase | B | 7.12 | pKd | 75 | nM | Kd | Bioorg Med Chem Lett (1997) 7: 2125-2130 |
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094108] [GtoPdb: 2825, 2826] [UniProtKB: P49354, P49356] | ||||||||
ChEMBL | Binding affinity to FTase (unknown origin) | B | 8.7 | pKd | 2 | nM | Kd | Medchemcomm (2013) 4: 476-492 [PMID:25530833] |
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
ChEMBL | Inhibitory activity against microsomal Squalene synthase | B | 5.59 | pKi | 2600 | nM | Ki | J Med Chem (1991) 34: 1912-1914 [PMID:2061928] |
mevalonate kinase in Human [GtoPdb: 640] [UniProtKB: Q03426] | ||||||||
GtoPdb | recombinant enzyme expressed in E coli cells. Spectrophotometric assay | - | 7 | pKi | 101 | nM | Ki | J Lipid Res (1997) 38: 2216-23 [PMID:9392419] |
GtoPdb | recombinant wild type enzyme expressed in E coli, in vitro spectrophotometric assay | - | 7.47 | pKi | 34 | nM | Ki | Biochemistry (2008) 47: 3715-24 [PMID:18302342] |
mevalonate kinase in Rat [GtoPdb: 640] [UniProtKB: P17256] | ||||||||
GtoPdb | in vitro, spectrophotometric assay | - | 5.6 | pKi | 2500 | nM | Ki | J Biol Chem (1990) 265: 2391-8 [PMID:2153681] |
GtoPdb | spectrophotometric in vitro assay | - | 6.46 | pKi | 348 | nM | Ki | J Bacteriol (2004) 186: 61-7 [PMID:14679225] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]