compound 16f [PMID: 18155906] [Ligand Id: 3011] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1207386
  • hydroxymethylglutaryl-CoA reductase in Rat [GtoPdb: 639] [UniProtKB: P51639]
Created with Highcharts 10.3.3ValuesChart context menuhydroxymethylglutaryl-CoA reductasepKd RatpKi RatpIC50 RatpEC50 Rat0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
hydroxymethylglutaryl-CoA reductase in Rat [GtoPdb: 639] [UniProtKB: P51639]
GtoPdb Inhibition of HMGCoA reductase - 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2008) 18: 1151-6 [PMID:18155906]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]