compound 5ab [PMID: 8246233] [Ligand Id: 2994] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL331048
  • hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639]
Created with Highcharts 10.3.3ValuesChart context menuHMG-CoA reductasepKd RatpKi RatpIC50 RatpEC50 Rat0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639]
GtoPdb In vitro inhibition of HMG-CoA reductase - 9 pIC50 1 nM IC50 J Med Chem (1993) 36: 3646-57 [PMID:8246233]
ChEMBL Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR) B 9 pIC50 1 nM IC50 J Med Chem (1993) 36: 3646-3657 [PMID:8246233]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]