LPA [Ligand Id: 2906] activity data from GtoPdb

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  • LPA4 receptor in Human [GtoPdb: 94] [UniProtKB: Q99677]
  • LPA4 receptor in Mouse [GtoPdb: 94] [UniProtKB: Q8BLG2]
Created with Highcharts 10.3.3ValuesChart context menuLPA4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 Mouse02468Highcharts.com
  • GPR87 in Human [GtoPdb: 122] [UniProtKB: Q9BY21]
Created with Highcharts 10.3.3ValuesChart context menuGPR87pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • LPA5 receptor in Human [GtoPdb: 124] [UniProtKB: Q9H1C0]
Created with Highcharts 10.3.3ValuesChart context menuLPA5 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • LPA6 receptor in Human [GtoPdb: 163] [UniProtKB: P43657]
  • LPA6 receptor in Mouse [GtoPdb: 163] [UniProtKB: Q8BMC0]
Created with Highcharts 10.3.3ValuesChart context menuLPA6 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 Mouse01234567Highcharts.com
  • P2RY10 in Human [GtoPdb: 165] [UniProtKB: O00398]
Created with Highcharts 10.3.3ValuesChart context menuP2RY10pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • LPA1 receptor in Mouse [GtoPdb: 272] [UniProtKB: P61793]
Created with Highcharts 10.3.3ValuesChart context menuLPA1 receptorpKd MousepKi MousepIC50 MousepEC50 Mouse0246810Highcharts.com
  • LPA2 receptor in Human [GtoPdb: 273] [UniProtKB: Q9HBW0]
  • LPA2 receptor in Mouse [GtoPdb: 273] [UniProtKB: Q9JL06]
Created with Highcharts 10.3.3ValuesChart context menuLPA2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 Mouse0246810Highcharts.com
  • LPA3 receptor in Human [GtoPdb: 274] [UniProtKB: Q9UBY5]
  • LPA3 receptor in Mouse [GtoPdb: 274] [UniProtKB: Q9EQ31]
Created with Highcharts 10.3.3ValuesChart context menuLPA3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 Mouse02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LPA4 receptor in Human [GtoPdb: 94] [UniProtKB: Q99677]
GtoPdb - - 7.35 pKd - - - J Biol Chem (2003) 278: 25600-6 [PMID:12724320]
LPA4 receptor in Mouse [GtoPdb: 94] [UniProtKB: Q8BLG2]
GtoPdb - - 7.35 pKd 45 nM Kd J Biol Chem (2003) 278: 25600-6 [PMID:12724320]
GPR87 in Human [GtoPdb: 122] [UniProtKB: Q9BY21]
GtoPdb - - 7.44 pEC50 - - - Biochem Biophys Res Commun (2007) 363: 861-6 [PMID:17905198];
Biochem Biophys Res Commun (2008) 371: 707-12 [PMID:18466763]
LPA5 receptor in Human [GtoPdb: 124] [UniProtKB: Q9H1C0]
GtoPdb - - 8.19 pKd 6.4 nM Kd J Pharmacol Exp Ther (2006) 318: 619-28 [PMID:16651401]
GtoPdb - - 7.9 pEC50 - - - J Biol Chem (2008) 283: 21054-64 [PMID:18499677];
Bioorg Med Chem (2010) 18: 477-95 [PMID:20056548];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]
LPA6 receptor in Human [GtoPdb: 163] [UniProtKB: P43657]
GtoPdb - - 6 pEC50 - - - J Biol Chem (2009) 284: 17731-41 [PMID:19386608];
Nat Genet (2008) 40: 329-34 [PMID:18297070]
LPA6 receptor in Mouse [GtoPdb: 163] [UniProtKB: Q8BMC0]
GtoPdb - - 6 pEC50 1000 nM EC50 J Biol Chem (2009) 284: 17731-41 [PMID:19386608]
P2RY10 in Human [GtoPdb: 165] [UniProtKB: O00398]
GtoPdb - - 6.9 pEC50 - - - Biochem Biophys Res Commun (2008) 371: 707-12 [PMID:18466763]
LPA1 receptor in Mouse [GtoPdb: 272] [UniProtKB: P61793]
GtoPdb - - 8.3 pEC50 5 nM EC50 Curr Med Chem (2008) 15: 2122-31 [PMID:18781939];
J Cell Biol (1996) 135: 1071-83 [PMID:8922387];
J Neurosci (2010) 30: 7300-9 [PMID:20505096]
LPA2 receptor in Human [GtoPdb: 273] [UniProtKB: Q9HBW0]
GtoPdb - - 8.16 pEC50 - - - Mol Pharmacol (2000) 57: 753-9 [PMID:10727522];
Bioorg Med Chem Lett (2004) 14: 3473-6 [PMID:15177455]
LPA2 receptor in Mouse [GtoPdb: 273] [UniProtKB: Q9JL06]
GtoPdb - - 8.17 pEC50 6.8 nM EC50 Curr Med Chem (2008) 15: 2122-31 [PMID:18781939];
J Biol Chem (1998) 273: 7906-10 [PMID:9525886]
LPA3 receptor in Human [GtoPdb: 274] [UniProtKB: Q9UBY5]
GtoPdb - - 6.69 pKd - - - J Biol Chem (1999) 274: 27776-85 [PMID:10488122]
LPA3 receptor in Mouse [GtoPdb: 274] [UniProtKB: Q9EQ31]
GtoPdb - - 6.6 pEC50 253 nM EC50 Curr Med Chem (2008) 15: 2122-31 [PMID:18781939]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.