nilutamide [Ligand Id: 2864] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1274 (Anadron, Nilandron, Nilutamida, Nilutamide, NSC-758683, RU 23908, RU-23908) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Inhibition of Androgen receptor (unknown origin) | B | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2022) 230: 114119-114119 [PMID:35063736] |
| ChEMBL | Inhibition of wild-type androgen receptor in human LAPC4 cells assessed as inhibition of DHT-induced luciferase activity measured after 24 hrs by luciferase reporter assay | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2016) 59: 10705-10718 [PMID:27933964] |
| GtoPdb | - | - | 7.12 | pIC50 | 75 | nM | IC50 | Urology (1997) 49: 580-6; discussion 586-9 [PMID:9111629] |
| ChEMBL | Inhibition of 1.0 nM [3H]mibolerone binding to human androgen receptor of PC3/AR cell lysate | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2003) 46: 5258-5270 [PMID:14613328] |
| ChEMBL | Inhibition of [3H]mibolerone binding to human Androgen receptor of PC3/AR Cell Lysate | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2004) 47: 5690-5699 [PMID:15509168] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
