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ChEMBL ligand: CHEMBL15927 (Octadec-9-Enoic Acid Amide, Oleamide) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acyl coenzyme A:cholesterol acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2782] [UniProtKB: P35610] | ||||||||
ChEMBL | Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 1 | B | 4.07 | pIC50 | 85000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4277-4280 [PMID:15261286] |
ChEMBL | Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 2 | B | 4.2 | pIC50 | 63000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4277-4280 [PMID:15261286] |
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
ChEMBL | Inhibition of fatty acid amide hydrolase; range = 22-68 uM | B | 4.17 | pIC50 | 68000 | nM | IC50 | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
ChEMBL | Inhibition of [3H]CP-55940 binding to rat cannabinoid receptor 1 | B | 5.94 | pKi | 1140 | nM | Ki | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O09028, P15431, P18506, P18508, P19969, P20236, P23574, P23576, P28471, P28473, P30191, P62813, P63079, P63138, Q91ZM7, Q9ES14] | ||||||||
ChEMBL | Inhibitory activity against Gamma-aminobutyric acid A (GABA-A) receptor from rat cultured cortical neuron RNA expressed in Xenopus oocytes | F | 4.82 | pEC50 | 15000 | nM | EC50 | J Med Chem (2000) 43: 1427-1447 [PMID:10780899] |
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] | ||||||||
ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
GtoPdb | - | - | 8.6 | pKd | - | - | - | Biochem Pharmacol (1999) 58: 1807-13 [PMID:10571256] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]