propylpyrazoletriol [Ligand Id: 2819] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL441282 (Propylpyrazoletriol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
| GtoPdb | - | - | 9.64 | pKi | - | - | - |
J Med Chem (2000) 43: 4934-47 [PMID:11150164]; Endocrinology (2000) 141: 3534-45 [PMID:11014206] |
| ChEMBL | Activation of ERalpha in human MCF7/2a cells by luciferase reporter gene assay relative to untreated control | B | 8.52 | pEC50 | 3 | nM | EC50 | J Med Chem (2012) 55: 9607-9618 [PMID:23043242] |
| ChEMBL | Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control | B | 10 | pEC50 | 0.1 | nM | EC50 | J Med Chem (2012) 55: 9607-9618 [PMID:23043242] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
