ChEMBL ligand: CHEMBL1405 (1,3,5-estratrien-3-ol-17-one, Estradiol metabolite e1, Estrogenic substance, Estrone, Follicular hormone, Follicular-hormone, Folliculin, Folliculinum, Ketohydroxyestrin, Natural estrogenic substance-estrone, NSC-9699, Oestrone, Theelin, Thelykinin, Tokokin, WAY 164397)
Alpha-synuclein in Human [ChEMBL: CHEMBL6152] [UniProtKB: P37840] There should be some charts here, you may need to enable JavaScript!
Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] There should be some charts here, you may need to enable JavaScript!
Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
CYP1B1/Cytochrome P450 1B1 in Human [ChEMBL: CHEMBL4878] [GtoPdb: 1320] [UniProtKB: Q16678] There should be some charts here, you may need to enable JavaScript!
Estradiol 17-beta-dehydrogenase 1 in Human [ChEMBL: CHEMBL3181] [UniProtKB: P14061] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Progesterone receptor in Bovine [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Steryl-sulfatase in Human [ChEMBL: CHEMBL3559] [UniProtKB: P08842] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840]
ChEMBL	Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay	B	4.03	pIC50	93100	nM	IC50	Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)	B	5.11	pKi	7745	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)	B	4.93	pIC50	11617	nM	IC50	DrugMatrix in vitro pharmacology data
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	5.18	pIC50	6589	nM	IC50	DrugMatrix in vitro pharmacology data
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	TP_TRANSPORTER: drug resistance(SN-38) in BCRP-expressing K562 cells	F	5	pIC50	>10000	nM	IC50	Mol Cancer Ther (2003) 2: 105-112 [PMID:12533678]
ChEMBL	TP_TRANSPORTER: drug resistance(Mitoxantrone) in BCRP-expressing K562 cells	F	5.52	pIC50	3000	nM	IC50	Mol Cancer Ther (2003) 2: 105-112 [PMID:12533678]
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	In silico binding affinity to human corticosteriod binding globulin	B	4	pKd	4	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	5	pKi	10000	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]AD	B	5.6	pKi	2500	nM	Ki	Eur J Med Chem (2015) 105: 1-38 [PMID:26469743]
CYP1B1/Cytochrome P450 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4878] [GtoPdb: 1320] [UniProtKB: Q16678]
ChEMBL	Inhibition of recombinant human CYP1B1 expressed in bacterial microsomes co-expressing P450 reductase using 7-ethyl-O-resorufin as substrate after 45 mins in presence of NADPH by fluorescence assay	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 5272-5276 [PMID:27687674]
Estradiol 17-beta-dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3181] [UniProtKB: P14061]
ChEMBL	Inhibition of human estradiol 17beta-dehydrogenase	B	5.02	pKi	9500	nM	Ki	J Med Chem (2011) 54: 2529-2591 [PMID:21413808]
ChEMBL	Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+	B	8.52	pKi	3	nM	Ki	Eur J Med Chem (2008) 43: 2298-2306 [PMID:18372081]
ChEMBL	Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH	B	6.09	pIC50	810	nM	IC50	Eur J Med Chem (2008) 43: 2298-2306 [PMID:18372081]
ChEMBL	Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol	B	6.22	pIC50	600	nM	IC50	Eur J Med Chem (2008) 43: 2298-2306 [PMID:18372081]
ChEMBL	Inhibition of 17-beta HSD1 in T47D cells	F	6.48	pIC50	330	nM	IC50	J Med Chem (2006) 49: 1325-1345 [PMID:16480268]
ChEMBL	Inhibition of 17beta-HSD1 in human T47D cells assessed as inhibition of transformation of [14C]-estrone into [14C]estrogen	B	6.66	pIC50	218	nM	IC50	Bioorg Med Chem (2008) 16: 1849-1860 [PMID:18035543]
ChEMBL	Inhibition of His-tagged human 17beta-HSD1 expressed in Escherichia coli by scintillation counting	B	6.96	pIC50	109	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6740-6744 [PMID:19836949]
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
GtoPdb	-	-	8.5	pKi	-	-	-	Endocrinology (1997) 138: 863-70 [PMID:9048584]
ChEMBL	DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)	B	8.66	pKi	2.19	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity towards estrogen receptor alpha by [3H]17-beta-estradiol displacement.	B	6.68	pIC50	210	nM	IC50	Bioorg Med Chem Lett (2004) 14: 2327-2330 [PMID:15081034]
ChEMBL	Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells	B	7.02	pIC50	96	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6740-6744 [PMID:19836949]
ChEMBL	Displacement of [3H]estrone from ER alpha	B	7.54	pIC50	29	nM	IC50	J Med Chem (2006) 49: 2440-2455 [PMID:16610787]
ChEMBL	DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)	B	8.12	pIC50	7.65	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor alpha.	B	6.32	pEC50	480	nM	EC50	J Med Chem (2002) 45: 1399-1401 [PMID:11906280]
ChEMBL	Ability to activate estrogen receptor 1-mediated transcription.	F	6.92	pEC50	120	nM	EC50	Bioorg Med Chem Lett (2004) 14: 2327-2330 [PMID:15081034]
ChEMBL	Antagonist activity at full length human ERalpha receptor assessed as inhibition of estradiol-induced activation incubated for 22 to 24 hrs by cell based luciferase reporter gene assay	B	7.3	pEC50	>50	nM	EC50	Bioorg Med Chem (2020) 28: 115670-115670 [PMID:32912438]
ChEMBL	Activity at human recombinant ERalpha by fluorescence polarization assay	B	8.15	pEC50	7	nM	EC50	J Med Chem (2009) 52: 6660-6671 [PMID:19824648]
ChEMBL	Agonist activity at full length human ERalpha receptor assessed as transcriptional activity incubated for 22 to 24 hrs by cell based luciferase reporter gene assay	B	8.62	pEC50	2.4	nM	EC50	Bioorg Med Chem (2020) 28: 115670-115670 [PMID:32912438]
ChEMBL	Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha.	B	9.15	pEC50	0.7	nM	EC50	J Med Chem (2002) 45: 1399-1401 [PMID:11906280]
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
GtoPdb	-	-	7.93	pKi	-	-	-	Endocrinology (1997) 138: 863-70 [PMID:9048584]
ChEMBL	Binding affinity towards estrogen receptor beta by [3H]17-beta-estradiol displacement.	B	6.27	pIC50	540	nM	IC50	Bioorg Med Chem Lett (2004) 14: 2327-2330 [PMID:15081034]
ChEMBL	Displacement of [3H]estrone from ER beta	B	7.51	pIC50	31	nM	IC50	J Med Chem (2006) 49: 2440-2455 [PMID:16610787]
ChEMBL	Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor beta.	B	5.95	pEC50	1135	nM	EC50	J Med Chem (2002) 45: 1399-1401 [PMID:11906280]
ChEMBL	Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay at 10 uM	F	6.78	pEC50	166	nM	EC50	J Med Chem (2006) 49: 2440-2455 [PMID:16610787]
ChEMBL	Ability to activate estrogen receptor 2-mediated transcription.	F	6.92	pEC50	120	nM	EC50	Bioorg Med Chem Lett (2004) 14: 2327-2330 [PMID:15081034]
ChEMBL	Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay	F	7.59	pEC50	26	nM	EC50	J Med Chem (2006) 49: 2440-2455 [PMID:16610787]
ChEMBL	Antagonist activity at full length human ERbeta receptor assessed as inhibition of estradiol-induced activation incubated for 22 to 24 hrs by cell based luciferase reporter gene assay	B	8	pEC50	>10	nM	EC50	Bioorg Med Chem (2020) 28: 115670-115670 [PMID:32912438]
ChEMBL	Activity at human recombinant ERbeta by fluorescence polarization assay	B	8.1	pEC50	8	nM	EC50	J Med Chem (2009) 52: 6660-6671 [PMID:19824648]
ChEMBL	Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta.	B	8.68	pEC50	2.1	nM	EC50	J Med Chem (2002) 45: 1399-1401 [PMID:11906280]
ChEMBL	Displacement of fluormone from GST-tagged ERbeta receptor LBD (unknown origin) measured after 60 mins by TR-FRET competitive binding assay	B	9.03	pEC50	0.94	nM	EC50	Bioorg Med Chem (2020) 28: 115670-115670 [PMID:32912438]
ChEMBL	Agonist activity at full length human ERbeta receptor assessed as transcriptional activity incubated for 22 to 24 hrs by cell based luciferase reporter gene assay	B	9.3	pEC50	0.5	nM	EC50	Bioorg Med Chem (2020) 28: 115670-115670 [PMID:32912438]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	5.2	pIC50	6309.57	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5.4	pIC50	3981.07	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Progesterone receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	5.68	pKi	2100	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	4.79	pIC50	16098	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	5.06	pKi	8676	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	4.87	pIC50	13630	nM	IC50	DrugMatrix in vitro pharmacology data
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	5.55	pKi	2816	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	5.28	pIC50	5301	nM	IC50	DrugMatrix in vitro pharmacology data
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing HeLa cells	F	4.8	pKi	15700	nM	Ki	Am J Physiol (1996) 270: F326-F331 [PMID:8779894]
Steryl-sulfatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559] [UniProtKB: P08842]
ChEMBL	Inhibition of human steroid sulfatase using 4-methylumbelliferyl sulfate substrate after 10 mins by fluorescence assay	B	4.29	pIC50	51000	nM	IC50	Bioorg Med Chem (2011) 19: 5999-6005 [PMID:21925885]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Binding affinity towards human testosterone binding globulin.	B	7.18	pKd	7.18	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	8.18	pKd	6.61	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]