androstenol [Ligand Id: 2761] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL142348 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Constitutive androstane receptor/Nuclear receptor subfamily 1 group I member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5503] [GtoPdb: 607] [UniProtKB: Q14994] | ||||||||
| ChEMBL | Inhibition of GST-tagged human CAR LBD incubated for 90 mins by TR-FRET assay | B | 6.47 | pIC50 | 338.7 | nM | IC50 | ACS Med Chem Lett (2024) 15: 1987-1996 [PMID:39563813] |
| ChEMBL | Inhibition of GST-tagged human CAR LBD incubated for 90 mins in presence of Cy5-PGC1-alpha by HTRF co-activator assay | B | 6.6 | pIC50 | 249.8 | nM | IC50 | ACS Med Chem Lett (2024) 15: 1987-1996 [PMID:39563813] |
| Nuclear receptor subfamily 1 group I member 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3069] [UniProtKB: O35627] | ||||||||
| ChEMBL | Inhibitory concentration against mammalian m-constitutive androstane receptor (mCAR) activity | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2003) 46: 4687-4695 [PMID:14561088] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
