lanosterol [Ligand Id: 2746] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL225111 (Lanostereol)
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  • Farnesoid X receptor-β in Mouse [GtoPdb: 604]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-crystallin B chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621022] [UniProtKB: P02511]
ChEMBL Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control B 5.85 pEC50 1420 nM EC50 J Med Chem (2018) 61: 8693-8706 [PMID:30153006]
Farnesoid X receptor-β in Mouse [GtoPdb: 604]
GtoPdb - - 6 pEC50 - - - Mol Cell Biol (2003) 23: 864-72 [PMID:12529392]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]