ChEMBL ligand: CHEMBL981 (Fenocor-67, Fenofibrate free acid, Fenofibrate related compound b, Fenofibric acid, Fenogal, Fibricor, LF-153, Lipanthyl, Lipofen, Lofibra, NSC-281318, Procetofenic acid, Supralip, Trilipix)
fatty acid binding protein 2/Fatty acid binding protein intestinal in Human [ChEMBL: CHEMBL4879] [GtoPdb: 2532] [UniProtKB: P12104] There should be some charts here, you may need to enable JavaScript!
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Mouse [ChEMBL: CHEMBL2128] [GtoPdb: 593] [UniProtKB: P23204] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
fatty acid binding protein 2/Fatty acid binding protein intestinal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879] [GtoPdb: 2532] [UniProtKB: P12104]
ChEMBL	Displacement of 1-anilinonaphthalene-8-sulphonic acid from I-FABP	B	6	pKi	1000	nM	Ki	J Med Chem (2008) 51: 3755-3764 [PMID:18533710]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
ChEMBL	Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 42 deg C by fluorimetric assay	B	4.54	pKd	29000	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 37 deg C by fluorimetric assay	B	4.55	pKd	28000	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 30 deg C by fluorimetric assay	B	4.57	pKd	27000	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 25 deg C by fluorimetric assay	B	4.62	pKd	24000	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 20 deg C by fluorimetric assay	B	4.64	pKd	23000	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 15 deg C by fluorimetric assay	B	4.7	pKd	20000	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 10 deg C by fluorimetric assay	B	4.72	pKd	19000	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 5 deg C by fluorimetric assay	B	4.74	pKd	18000	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 37 deg C by fluorimetric assay	B	6.38	pKd	420	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 30 deg C by fluorimetric assay	B	6.44	pKd	360	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 25 deg C by fluorimetric assay	B	6.47	pKd	340	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 20 deg C by fluorimetric assay	B	6.66	pKd	220	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 15 deg C by fluorimetric assay	B	6.8	pKd	160	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 10 deg C by fluorimetric assay	B	7	pKd	100	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 5 deg C by fluorimetric assay	B	7.03	pKd	94	nM	Kd	J Med Chem (2009) 52: 5344-5355 [PMID:19663428]
ChEMBL	Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay	B	4.56	pKi	27500	nM	Ki	J Med Chem (2008) 51: 3755-3764 [PMID:18533710]
ChEMBL	Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay	B	6.48	pKi	334	nM	Ki	J Med Chem (2008) 51: 3755-3764 [PMID:18533710]
GtoPdb	-	-	6.48	pKi	334	nM	Ki	J Med Chem (2008) 51: 3755-64 [PMID:18533710]
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL	Binding affinity towards peroxisome proliferator activated receptor alpha (PPAR alpha)	B	4.46	pKi	35000	nM	Ki	Bioorg Med Chem Lett (2003) 13: 3185-3190 [PMID:12951090]
ChEMBL	Binding affinity towards human peroxidase proliferator activated receptor alpha (hPPARalpha)	B	4.17	pIC50	68000	nM	IC50	J Med Chem (2001) 44: 2061-2064 [PMID:11405642]
ChEMBL	Inhibition of human Peroxisome proliferator activated receptor alpha binding	B	4.46	pIC50	35000	nM	IC50	J Med Chem (2005) 48: 2262-2265 [PMID:15801817]
ChEMBL	Inhibitory activity against human Peroxisome proliferator activated receptor alpha	B	4.62	pIC50	24000	nM	IC50	J Med Chem (2003) 46: 5121-5124 [PMID:14613314]
ChEMBL	Mean inhibitory concentration against human peroxisome proliferator activated receptor alpha	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 51-55 [PMID:15582409]
ChEMBL	Inhibition of human Peroxisome proliferator activated receptor alpha	B	5	pIC50	>10000	nM	IC50	J Med Chem (2005) 48: 2248-2250 [PMID:15771468]
ChEMBL	Displacement of tritium labeled ligand from human PPARalpha by SPA assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 6293-6297 [PMID:17005393]
ChEMBL	Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalpha	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 6328-6333 [PMID:17005394]
ChEMBL	Agonist activity at human PPARalpha expressed in CV1 cells by transactivation assay	F	4	pEC50	>100000	nM	EC50	Bioorg Med Chem (2008) 16: 981-994 [PMID:17964792]
ChEMBL	Agonist activity at human PPARalpha by luciferase reporter transactivation assay	F	4.16	pEC50	69000	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2468-2473 [PMID:19349176]
ChEMBL	In vitro transactivation of human Peroxisome proliferator activated receptor alpha (hPPARalpha)	B	4.49	pEC50	32050	nM	EC50	J Med Chem (2003) 46: 4883-4894 [PMID:14584939]
ChEMBL	Compound was tested for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected CV-1 cells	F	4.52	pEC50	30000	nM	EC50	J Med Chem (1999) 42: 3785-3788 [PMID:10508427]
ChEMBL	Agonist activity at human PPARalpha expressed in monkey CV1 cells by transactivation assay	F	4.52	pEC50	30000	nM	EC50	Bioorg Med Chem Lett (2008) 18: 2128-2132 [PMID:18280733]
ChEMBL	Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in human HepG2 cells assessed as receptor transactivation by luciferase reporter gene assay	B	4.52	pEC50	30000	nM	EC50	J Med Chem (2009) 52: 6382-6393 [PMID:19775169]
ChEMBL	Agonist activity at PPARalpha (unknown origin)	B	4.52	pEC50	30000	nM	EC50	J Med Chem (2020) 63: 5031-5073 [PMID:31930920]
ChEMBL	Effective concentration against human Peroxisome proliferator activated receptor alpha in Gal4 transactivation assay	B	4.82	pEC50	15000	nM	EC50	J Med Chem (2005) 48: 2262-2265 [PMID:15801817]
ChEMBL	Cotransfection activity of compound against human Peroxisome proliferator activated receptor alpha was determined	F	4.89	pEC50	13000	nM	EC50	J Med Chem (2003) 46: 5121-5124 [PMID:14613314]
ChEMBL	Partial agonist activity at human PPARalpha expressed in CHO cells co-transfected with Gal4-responsive luciferase reporter plasmid after 24 hrs by transactivation assay	F	4.92	pEC50	12000	nM	EC50	Bioorg Med Chem Lett (2011) 21: 1978-1982 [PMID:21377875]
ChEMBL	Agonist activity at human PPARalpha ligand binding domain expressed in COS-1 cells co-transfected with Gal4 by luciferase reporter gene assay	B	4.92	pEC50	12000	nM	EC50	Bioorg Med Chem Lett (2011) 21: 220-224 [PMID:21130649]
ChEMBL	Displacement of tritium labeled ligand from human PPARalpha by SPA assay	B	5	pEC50	>10000	nM	EC50	Bioorg Med Chem Lett (2006) 16: 6293-6297 [PMID:17005393]
ChEMBL	Activity at human liver PPAR alpha expressed in HEK293 cells by PPAR-GAL4 transactivation assay	B	5	pEC50	>10000	nM	EC50	J Med Chem (2007) 50: 1495-1503 [PMID:17343371]
ChEMBL	Mean effective concentration against human peroxisome proliferator activated receptor alpha	B	5	pEC50	>10000	nM	EC50	Bioorg Med Chem Lett (2005) 15: 51-55 [PMID:15582409]
ChEMBL	Effective concentration against human Peroxisome proliferator activated receptor alpha	B	5	pEC50	>10000	nM	EC50	J Med Chem (2005) 48: 2248-2250 [PMID:15771468]
ChEMBL	Agonist activity at human recombinant PPARalpha by transactivation of TK-MH100x4-LUC reporter gene in HEK293 cells	F	5.04	pEC50	9200	nM	EC50	Bioorg Med Chem Lett (2006) 16: 3213-3218 [PMID:16617018]
ChEMBL	Binding affinity to histidine-tagged human PPARalpha-LBD assessed as recruitment of co-activator peptide fluorescein-labeled PGC1alpha after 2 hrs by TR-FRET assay	B	5.35	pEC50	4500	nM	EC50	Bioorg Med Chem Lett (2011) 21: 5876-5880 [PMID:21855333]
ChEMBL	Activity at human PPARalpha in CV1 cells	B	5.58	pEC50	2646	nM	EC50	Bioorg Med Chem Lett (2006) 16: 6328-6333 [PMID:17005394]
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2128] [GtoPdb: 593] [UniProtKB: P23204]
ChEMBL	Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 cells	F	4.74	pEC50	18000	nM	EC50	J Med Chem (1999) 42: 3785-3788 [PMID:10508427]
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
ChEMBL	Agonist activity at human PPARdelta expressed in CV1 cells by transactivation assay	F	4	pEC50	>100000	nM	EC50	Bioorg Med Chem (2008) 16: 981-994 [PMID:17964792]
ChEMBL	Agonist activity at human PPARdelta expressed in monkey CV1 cells by transactivation assay	F	4	pEC50	>100000	nM	EC50	Bioorg Med Chem Lett (2008) 18: 2128-2132 [PMID:18280733]
ChEMBL	Activity at human placenta PPAR delta expressed in HEK293 cells by PPAR-GAL4 transactivation assay	B	5	pEC50	>10000	nM	EC50	J Med Chem (2007) 50: 1495-1503 [PMID:17343371]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Inhibition of human Peroxisome proliferator activated receptor gamma binding	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2005) 48: 2262-2265 [PMID:15801817]
ChEMBL	Inhibition of human Peroxisome proliferator activated receptor gamma	B	4.6	pIC50	>25000	nM	IC50	J Med Chem (2005) 48: 2248-2250 [PMID:15771468]
ChEMBL	Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 51-55 [PMID:15582409]
ChEMBL	Displacement of tritium labeled ligand from human PPARgamma by SPA assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 6293-6297 [PMID:17005393]
ChEMBL	Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgamma	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 6328-6333 [PMID:17005394]
ChEMBL	Effective concentration against human Peroxisome proliferator activated receptor gamma in Gal4 transactivation assay	B	4	pEC50	>100000	nM	EC50	J Med Chem (2005) 48: 2262-2265 [PMID:15801817]
ChEMBL	Effective concentration against human Peroxisome proliferator activated receptor gamma	B	4	pEC50	>100000	nM	EC50	J Med Chem (2005) 48: 2248-2250 [PMID:15771468]
ChEMBL	Agonist activity at human PPARgamma expressed in CV1 cells by transactivation assay	F	4	pEC50	100000	nM	EC50	Bioorg Med Chem (2008) 16: 981-994 [PMID:17964792]
ChEMBL	Agonist activity at human PPARgamma expressed in monkey CV1 cells by transactivation assay	F	4	pEC50	>100000	nM	EC50	Bioorg Med Chem Lett (2008) 18: 2128-2132 [PMID:18280733]
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37]
ChEMBL	Inhibition of URAT1 (unknown origin)	B	4.96	pIC50	11000	nM	IC50	Medchemcomm (2016) 7: 1587-1595

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]