ChEMBL ligand: CHEMBL410478 (GW409544)
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL	Binding affinity for human peroxisome proliferator activated receptor alpha	B	8.7	pKi	2	nM	Ki	J Med Chem (2004) 47: 4118-4127 [PMID:15293980]
GtoPdb	-	-	8.7	pIC50	-	-	-	J Med Chem (2004) 47: 4118-27 [PMID:15293980]; Proc Natl Acad Sci USA (2001) 98: 13919-24 [PMID:11698662]
ChEMBL	Agonist activity at human PPAR-alpha	B	6.62	pEC50	240	nM	EC50	Bioorg Med Chem Lett (2014) 24: 2267-2272 [PMID:24745969]
ChEMBL	Agonist activity at human GAL4-tagged PPARalpha chimeric receptor expressed in HEK cells by transactivation assay	F	8	pEC50	10	nM	EC50	Bioorg Med Chem Lett (2010) 20: 2605-2608 [PMID:20299214]
ChEMBL	Agonist activity at human PPARalpha	F	8.64	pEC50	2.3	nM	EC50	Bioorg Med Chem (2008) 16: 3800-3808 [PMID:18272370]
ChEMBL	Agonist activity at GAL4-fused human PPARalpha LBD	B	8.64	pEC50	2.3	nM	EC50	Bioorg Med Chem Lett (2018) 28: 2717-2722 [PMID:29628329]
ChEMBL	Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assay	B	8.7	pEC50	2	nM	EC50	J Med Chem (2004) 47: 4118-4127 [PMID:15293980]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Binding affinity for human peroxisome proliferator activated receptor gamma	B	9	pKi	1	nM	Ki	J Med Chem (2004) 47: 4118-4127 [PMID:15293980]
ChEMBL	Agonist activity at human GAL4-tagged PPARgamma chimeric receptor expressed in HEK cells by transactivation assay	F	8.57	pEC50	2.7	nM	EC50	Bioorg Med Chem Lett (2010) 20: 2605-2608 [PMID:20299214]
GtoPdb	-	-	9.55	pEC50	-	-	-	J Med Chem (2004) 47: 4118-27 [PMID:15293980]; Proc Natl Acad Sci USA (2001) 98: 13919-24 [PMID:11698662]
ChEMBL	Agonist activity at human PPARgamma	F	9.55	pEC50	0.28	nM	EC50	Bioorg Med Chem (2008) 16: 3800-3808 [PMID:18272370]
ChEMBL	Agonist activity at GAL4-fused human PPARgamma LBD	B	9.55	pEC50	0.28	nM	EC50	Bioorg Med Chem Lett (2018) 28: 2717-2722 [PMID:29628329]
ChEMBL	Effective concentration against human peroxisome proliferator activated receptor gamma in Gal4 transactivation assay	B	9.7	pEC50	0.2	nM	EC50	J Med Chem (2004) 47: 4118-4127 [PMID:15293980]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]