ChEMBL ligand: CHEMBL69367 (AM580)
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL	Binding affinity for baculovirus-expressed Retinoic acid receptor RAR alpha	B	7.44	pKd	36	nM	Kd	J Med Chem (1996) 39: 3035-3038 [PMID:8759622]
ChEMBL	Binding affinity fo retinoic acid receptor RAR alpha	B	7.44	pKd	36	nM	Kd	Bioorg Med Chem Lett (2002) 12: 3145-3148 [PMID:12372520]
ChEMBL	Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)	B	7.39	pIC50	41	nM	IC50	J Med Chem (2000) 43: 409-419 [PMID:10669568]
ChEMBL	Activity at RARalpha expressed in mouse NIH3T3 cells by R-SAT assay	B	7.1	pEC50	79.43	nM	EC50	J Med Chem (2009) 52: 1540-1545 [PMID:19239230]
ChEMBL	Agonist activity at RARalpha by TR-FRET assay	F	8.4	pEC50	4	nM	EC50	J Med Chem (2011) 54: 788-808 [PMID:21218783]
ChEMBL	Effective concentration for retinoic acid receptor RAR alpha transcriptional activation	F	8.7	pEC50	2	nM	EC50	Bioorg Med Chem Lett (2002) 12: 3145-3148 [PMID:12372520]
GtoPdb	-	-	9.52	pEC50	0.3	nM	EC50	Bioorg Med Chem Lett (2009) 19: 489-92 [PMID:19058965]
ChEMBL	Activity at human RARalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	B	9.52	pEC50	0.3	nM	EC50	Bioorg Med Chem Lett (2009) 19: 489-492 [PMID:19058965]
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL	Binding affinity for retinoic acid receptor RAR beta	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem Lett (2002) 12: 3145-3148 [PMID:12372520]
ChEMBL	Binding affinity for baculovirus-expressed Retinoic acid receptor RAR beta	B	5.87	pKd	1361	nM	Kd	J Med Chem (1996) 39: 3035-3038 [PMID:8759622]
ChEMBL	Transcriptional activity against RARbeta1	F	7.3	pEC50	50.12	nM	EC50	J Med Chem (2005) 48: 7517-7519 [PMID:16302793]
ChEMBL	Activity at RARbeta1 expressed in mouse NIH3T3 cells by R-SAT assay	B	7.3	pEC50	50.12	nM	EC50	J Med Chem (2009) 52: 1540-1545 [PMID:19239230]
ChEMBL	Transcriptional activity against RARbeta2	F	7.7	pEC50	19.95	nM	EC50	J Med Chem (2005) 48: 7517-7519 [PMID:16302793]
ChEMBL	Agonist activity at RARbeta2 expressed in mouse NIH3T3 cells by R-SAT assay	F	7.7	pEC50	19.95	nM	EC50	J Med Chem (2009) 52: 1540-1545 [PMID:19239230]
ChEMBL	Effective concentration for retinoic acid receptor RAR beta transcriptional activation	F	8.05	pEC50	9	nM	EC50	Bioorg Med Chem Lett (2002) 12: 3145-3148 [PMID:12372520]
ChEMBL	Activity at human RARbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	B	8.07	pEC50	8.6	nM	EC50	Bioorg Med Chem Lett (2009) 19: 489-492 [PMID:19058965]
GtoPdb	-	-	8.07	pEC50	8.6	nM	EC50	Bioorg Med Chem Lett (2009) 19: 489-92 [PMID:19058965]
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL	Binding affinity for baculovirus-expressed Retinoic acid receptor RAR gamma	B	5.42	pKd	3824	nM	Kd	J Med Chem (1996) 39: 3035-3038 [PMID:8759622]
ChEMBL	Binding affinity for retinoic acid receptor RAR gamma	B	5.42	pKd	3800	nM	Kd	Bioorg Med Chem Lett (2002) 12: 3145-3148 [PMID:12372520]
ChEMBL	Activity at RARgamma expressed in mouse NIH3T3 cells by R-SAT assay	B	7.6	pEC50	25.12	nM	EC50	J Med Chem (2009) 52: 1540-1545 [PMID:19239230]
ChEMBL	Effective concentration for retinoic acid receptor RAR gamma transcriptional activation	F	7.72	pEC50	19	nM	EC50	Bioorg Med Chem Lett (2002) 12: 3145-3148 [PMID:12372520]
ChEMBL	Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	B	7.89	pEC50	13	nM	EC50	Bioorg Med Chem Lett (2009) 19: 489-492 [PMID:19058965]
GtoPdb	-	-	7.89	pEC50	13	nM	EC50	Bioorg Med Chem Lett (2009) 19: 489-92 [PMID:19058965]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]