alitretinoin [Ligand Id: 2645] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL705 (9-cis retinoic acid, 9-cis-retinoic acid, AGN 192013, AGN-192013, Alitretinoin, ALRT-1057, ALRT1057, BAL-4079, LG-100057, LG100057, LGD-1057, LGD1057, NSC-659772, Panretin, Retinoic acid 9-cis-form, Toctino) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cellular retinoic acid-binding protein I in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4945] [UniProtKB: P40220] | ||||||||
| ChEMBL | Inhibition of [3H]ATRA binding to chick skin Cytoplasmic retinoic acid binding protein | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1996) 39: 3625-3635 [PMID:8809153] |
| cellular retinoic acid binding protein 1/Cellular retinoic acid-binding protein I in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3208] [GtoPdb: 2529] [UniProtKB: P62965] | ||||||||
| ChEMBL | Inhibition of [3H]ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 1 | B | 6.7 | pKd | >200 | nM | Kd | J Med Chem (1996) 39: 3625-3635 [PMID:8809153] |
| cellular retinoic acid binding protein 2/Cellular retinoic acid-binding protein II in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4172] [GtoPdb: 2530] [UniProtKB: P22935] | ||||||||
| ChEMBL | Inhibition of [3H]ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 2 | B | 6.7 | pKd | >200 | nM | Kd | J Med Chem (1996) 39: 3625-3635 [PMID:8809153] |
| Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] | ||||||||
| ChEMBL | Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay | B | 5.96 | pEC50 | 1090 | nM | EC50 | Bioorg Med Chem Lett (2017) 27: 1193-1198 [PMID:28169169] |
| Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] | ||||||||
| ChEMBL | Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay | B | 5.76 | pEC50 | 1730 | nM | EC50 | Bioorg Med Chem Lett (2017) 27: 1193-1198 [PMID:28169169] |
| RAR-related orphan receptor-γ/Nuclear receptor ROR-gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741186] [GtoPdb: 600] [UniProtKB: P51449] | ||||||||
| ChEMBL | Inverse agonist activity at human RoRc-LBD fusion protein with GST expressed in BL-21 (BL3) cells assessed as SRC1 coactivator peptide recruitment | B | 4.85 | pEC50 | 14000 | nM | EC50 | J Med Chem (2014) 57: 5871-5892 [PMID:24502334] |
| Nerve Growth factor IB/Nuclear receptor subfamily 4 group A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293229] [GtoPdb: 629] [UniProtKB: P22736] | ||||||||
| ChEMBL | Binding affinity to Nur77 Y453A mutant expressed in human BGC823 cells | B | 6.09 | pKd | 810 | nM | Kd | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] | ||||||||
| ChEMBL | Inhibition of [3H]RA binding to retinoic acid receptor RAR alpha | B | 7.03 | pKd | 93 | nM | Kd | Bioorg Med Chem Lett (1999) 9: 589-594 [PMID:10098670] |
| ChEMBL | Inhibition of [3H]ATRA binding to human Retinoic acid receptor RAR alpha | B | 7.03 | pKd | 93 | nM | Kd | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-alpha | B | 7.05 | pKd | 90 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 7.96 | pKd | 11 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
| GtoPdb | - | - | 9.5 | pKd | - | - | - |
J Med Chem (1988) 31: 2182-92 [PMID:3184125]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761] |
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR alpha | B | 7.65 | pKi | 22.3 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Binding affinity against retinoic Acid alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | F | 6.52 | pEC50 | 304 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR alpha | B | 6.66 | pEC50 | 220 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Agonist activity for retinoic acid receptor RAR alpha in transcriptional activation assay | F | 6.72 | pEC50 | 191 | nM | EC50 | Bioorg Med Chem Lett (1995) 5: 2729-2734 |
| ChEMBL | Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells | B | 6.72 | pEC50 | 191 | nM | EC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay | B | 6.72 | pEC50 | 191 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR alpha | B | 6.72 | pEC50 | 191 | nM | EC50 | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR alpha | B | 6.99 | pEC50 | 102 | nM | EC50 | J Med Chem (1995) 38: 2820-2829 [PMID:7636843] |
| ChEMBL | Transcriptional activation for RAR alpha receptor | B | 6.99 | pEC50 | 102 | nM | EC50 | Bioorg Med Chem Lett (1994) 4: 1447-1452 |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR alpha | F | 6.99 | pEC50 | 102 | nM | EC50 | J Med Chem (1999) 42: 4961-4969 [PMID:10585206] |
| ChEMBL | Effective concentration against RAR-alpha receptor | B | 7.35 | pEC50 | 45 | nM | EC50 | J Med Chem (1993) 36: 2605-2613 [PMID:8410972] |
| ChEMBL | Relative activity against Retinoic acid receptor RAR alpha compared to ATRA | B | 7.64 | pEC50 | 23 | nM | EC50 | J Med Chem (1995) 38: 3368-3383 [PMID:7650690] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR alpha | F | 7.68 | pEC50 | 21 | nM | EC50 | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| Retinoic acid receptor-α/Retinoic acid receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2792] [GtoPdb: 590] [UniProtKB: P11416] | ||||||||
| ChEMBL | Dissociation constant for binding to Retinoic acid receptor alpha | B | 8.15 | pKd | 7 | nM | Kd | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Inhibition of [3H]ATRA binding to mouse Retinoic acid receptor RAR alpha | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1996) 39: 3625-3635 [PMID:8809153] |
| Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] | ||||||||
| ChEMBL | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-beta | B | 7 | pKd | 100 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| ChEMBL | Inhibition of [3H]RA binding to retinoic acid receptor RAR beta | B | 7.01 | pKd | 97 | nM | Kd | Bioorg Med Chem Lett (1999) 9: 589-594 [PMID:10098670] |
| ChEMBL | Inhibition of [3H]-ATRA binding to human Retinoic acid receptor RAR beta | B | 7.01 | pKd | 97 | nM | Kd | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 8.15 | pKd | 7 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR beta | B | 7.96 | pKi | 10.9 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RA | B | 9.15 | pKi | 0.7 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 2313-2318 |
| ChEMBL | Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA | B | 9.3 | pKi | 0.5 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 2313-2318 |
| GtoPdb | - | - | 9.7 | pKi | - | - | - |
J Mol Biol (2000) 302: 155-70 [PMID:10964567]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761] |
| ChEMBL | Binding affinity against retinoic Acid beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | F | 7.28 | pEC50 | 52 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay | F | 7.3 | pEC50 | 50 | nM | EC50 | Bioorg Med Chem Lett (1995) 5: 2729-2734 |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR beta | B | 7.3 | pEC50 | 50 | nM | EC50 | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay | B | 7.3 | pEC50 | 50 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells | B | 7.3 | pEC50 | 50 | nM | EC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR beta | B | 7.54 | pEC50 | 29 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Effective concentration against Retinoic acid receptor beta | B | 7.66 | pEC50 | 22 | nM | EC50 | J Med Chem (1993) 36: 2605-2613 [PMID:8410972] |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR beta | F | 8.48 | pEC50 | 3.3 | nM | EC50 | J Med Chem (1999) 42: 4961-4969 [PMID:10585206] |
| ChEMBL | Transcriptional activation for RAR beta receptor | B | 8.48 | pEC50 | 3.3 | nM | EC50 | Bioorg Med Chem Lett (1994) 4: 1447-1452 |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR beta | B | 8.48 | pEC50 | 3.3 | nM | EC50 | J Med Chem (1995) 38: 2820-2829 [PMID:7636843] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR beta | F | 8.52 | pEC50 | 3 | nM | EC50 | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| Retinoic acid receptor-β/Retinoic acid receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3266] [GtoPdb: 591] [UniProtKB: P22605] | ||||||||
| ChEMBL | Dissociation constant for binding to Retinoic acid receptor beta | B | 8.15 | pKd | 7 | nM | Kd | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] | ||||||||
| ChEMBL | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-gamma | B | 6.82 | pKd | 150 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| ChEMBL | Inhibition of [3H]RA binding to retinoic acid receptor RAR gamma | B | 6.83 | pKd | 148 | nM | Kd | Bioorg Med Chem Lett (1999) 9: 589-594 [PMID:10098670] |
| ChEMBL | Inhibition of [3H]ATRA binding to human Retinoic acid receptor RAR gamma | B | 6.83 | pKd | 148 | nM | Kd | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor | B | 7.66 | pKd | 22 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
| GtoPdb | - | - | 9 | pKd | - | - | - |
J Mol Biol (2000) 302: 155-70 [PMID:10964567]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761] |
| ChEMBL | Dissociation constant for Retinoic acid receptor gamma | B | 9.1 | pKd | 0.8 | nM | Kd | J Med Chem (2005) 48: 6212-6219 [PMID:16190748] |
| ChEMBL | Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR gamma | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Agonistic activity towards retinoic acid receptor-gamma | F | 9 | pKi | 1 | nM | Ki | J Med Chem (1997) 40: 4222-4234 [PMID:9435893] |
| ChEMBL | Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | F | 7.13 | pEC50 | 74 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing human Retinoic acid receptor RAR gamma | B | 7.3 | pEC50 | 50 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay | F | 7.35 | pEC50 | 45 | nM | EC50 | Bioorg Med Chem Lett (1995) 5: 2729-2734 |
| ChEMBL | Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells | B | 7.35 | pEC50 | 45 | nM | EC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay | B | 7.35 | pEC50 | 45 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR gamma | B | 7.35 | pEC50 | 45 | nM | EC50 | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Effective concentration against RAR-gamma receptor | B | 7.92 | pEC50 | 12 | nM | EC50 | J Med Chem (1993) 36: 2605-2613 [PMID:8410972] |
| ChEMBL | Transcriptional activation for RAR gamma receptor | B | 8.22 | pEC50 | 6 | nM | EC50 | Bioorg Med Chem Lett (1994) 4: 1447-1452 |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR gamma | F | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (1999) 42: 4961-4969 [PMID:10585206] |
| ChEMBL | Transcriptional activation of Retinoic acid receptor RAR gamma | B | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (1995) 38: 2820-2829 [PMID:7636843] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gamma | F | 8.4 | pEC50 | 4 | nM | EC50 | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| Retinoic acid receptor-γ/Retinoic acid receptor gamma in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4177] [GtoPdb: 592] [UniProtKB: P18911] | ||||||||
| ChEMBL | Dissociation constant for binding to Retinoic acid receptor gamma | B | 7.77 | pKd | 17 | nM | Kd | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] | ||||||||
| ChEMBL | Binding affinity to human RXRalpha LBD after 15 mins by isothermal titration calorimetry assay | B | 5.74 | pKd | 1810 | nM | Kd | J Med Chem (2015) 58: 7763-7774 [PMID:26331194] |
| ChEMBL | Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by isothermal titration calorimetry | B | 5.81 | pKd | 1560 | nM | Kd | J Med Chem (2014) 57: 5370-5380 [PMID:24801499] |
| ChEMBL | Binding affinity to RXRalpha | B | 6.62 | pKd | 240 | nM | Kd | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Dissociation constant for binding to Retinoic acid receptor RXR-alpha | B | 7.3 | pKd | 50 | nM | Kd | Bioorg Med Chem Lett (2002) 12: 2607-2609 [PMID:12182871] |
| ChEMBL | Binding affinity to human RXRalpha ligand binding domain by fluorescence assay | B | 7.85 | pKd | 14 | nM | Kd | Bioorg Med Chem (2014) 22: 178-185 [PMID:24359708] |
| ChEMBL | Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching method | B | 7.85 | pKd | 14 | nM | Kd | J Med Chem (2014) 57: 5370-5380 [PMID:24801499] |
| ChEMBL | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alpha | B | 7.89 | pKd | 13 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor | B | 8.05 | pKd | 9 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gamma | B | 8.1 | pKd | 8 | nM | Kd | Bioorg Med Chem Lett (1999) 9: 589-594 [PMID:10098670] |
| ChEMBL | Inhibition of [3H]9-cis-RA binding to human Retinoid X receptor RXR alpha | B | 8.1 | pKd | 8 | nM | Kd | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Inhibition of binding to human Retinoic acid receptor RXR DEF domain | B | 8.52 | pKd | 3 | nM | Kd | J Med Chem (1996) 39: 3625-3635 [PMID:8809153] |
| ChEMBL | Dissociation constant for Retinoid X receptor alpha | B | 8.82 | pKd | 1.5 | nM | Kd | J Med Chem (2005) 48: 6212-6219 [PMID:16190748] |
| ChEMBL | Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assay | B | 6.23 | pKi | 583 | nM | Ki | J Med Chem (2019) 62: 8809-8818 [PMID:31483660] |
| ChEMBL | Displacement of 6-(Ethyl-{5-isobutoxy-4-isopropyl-2-[(10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carbonyl)-amino]-phenyl}-amino)-nicotinic acid from human RXRalpha-LBD by by fluorescence binding assay | B | 6.32 | pKi | 478 | nM | Ki | J Med Chem (2021) 64: 861-870 [PMID:33378197] |
| ChEMBL | Agonistic activity towards retinoid X receptor-alpha | F | 7.92 | pKi | 12 | nM | Ki | J Med Chem (1997) 40: 4222-4234 [PMID:9435893] |
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR alpha | B | 8.08 | pKi | 8.4 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Inhibition of [3H]targretin binding to Retinoid X receptor RXR alpha | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (1996) 39: 3229-3234 [PMID:8765503] |
| ChEMBL | Binding affinity against retinoic Acid X alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | B | 7.49 | pIC50 | 32 | nM | IC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Inhibition of [3H]9-cis-retinoic acid binding to human retinoid X receptor alpha ligand-binding domain expressed in Escherichia coli | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2004) 47: 4360-4372 [PMID:15317450] |
| GtoPdb | - | - | 8.2 | pIC50 | - | - | - |
Proc Natl Acad Sci USA (1993) 90: 30-4 [PMID:8380496]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761]; Cell (1992) 68: 397-406 [PMID:1310260]; Nature (1996) 383: 450-3 [PMID:8837780]; Nature (1992) 355: 359-61 [PMID:1309942]; Genes Dev (1992) 6: 329-44 [PMID:1312497] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alpha | F | 6.5 | pEC50 | 316 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay | B | 6.6 | pEC50 | 250 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Transcriptional activation in CV-1 cells expressing human Retinoid X receptor RXR-alpha | B | 6.71 | pEC50 | 195 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay | B | 6.92 | pEC50 | 120 | nM | EC50 | J Med Chem (2014) 57: 5370-5380 [PMID:24801499] |
| ChEMBL | Agonist activity for retinoic acid receptor RXR alpha in transcriptional activation assay | F | 7 | pEC50 | 100 | nM | EC50 | Bioorg Med Chem Lett (1995) 5: 2729-2734 |
| ChEMBL | Binding affinity against retinoic Acid X alpha receptors co-transfected into CV-1 cells | B | 7 | pEC50 | 100 | nM | EC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Transcriptional activation of Retinoid X receptor RXR alpha | B | 7 | pEC50 | 100 | nM | EC50 | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Transcriptional activation of Retinoid X receptor RXR alpha | B | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (1995) 38: 2820-2829 [PMID:7636843] |
| ChEMBL | Transcriptional activation for RXR alpha receptor | B | 7.89 | pEC50 | 13 | nM | EC50 | Bioorg Med Chem Lett (1994) 4: 1447-1452 |
| ChEMBL | Effective concentration against RXR-alpha receptor | B | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (1993) 36: 2605-2613 [PMID:8410972] |
| ChEMBL | Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assay | B | 8 | pEC50 | 10 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 5265-5267 [PMID:25305688] |
| ChEMBL | Effective concentration against Retinoic acid receptor RXR-alpha | B | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (1995) 38: 3368-3383 [PMID:7650690] |
| ChEMBL | Agonist activity at human RXR-alpha | B | 8.4 | pEC50 | 4 | nM | EC50 | J Med Chem (2016) 59: 9201-9214 [PMID:27652492] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha | F | 8.82 | pEC50 | 1.5 | nM | EC50 | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| Retinoid X receptor-α/Retinoid X receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3084] [GtoPdb: 610] [UniProtKB: P28700] | ||||||||
| ChEMBL | Dissociation constant for binding to Retinoid X receptor alpha | B | 7.49 | pKd | 32 | nM | Kd | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alpha | B | 7.09 | pIC50 | 82 | nM | IC50 | J Med Chem (1996) 39: 3625-3635 [PMID:8809153] |
| ChEMBL | Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after 6 hrs by Dual-light chemiluminescent assay | B | 6.7 | pEC50 | 200 | nM | EC50 | Eur J Med Chem (2009) 44: 2434-2446 [PMID:19216008] |
| Retinoid X receptor-α/Retinoid X receptor alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4431] [GtoPdb: 610] [UniProtKB: Q05343] | ||||||||
| ChEMBL | Agonist activity at RXRalpha in rat RK3E cells assessed as transcriptional activation by luciferase reporter gene assay | B | 6.92 | pEC50 | 120 | nM | EC50 | Bioorg Med Chem (2014) 22: 178-185 [PMID:24359708] |
| ChEMBL | Agonist activity at RXR-alpha in rat R3KE cells infected with oncogene KLF4-ER assessed as inhibition of KLF4-mediated oncogenic transformation | B | 6.96 | pEC50 | 110 | nM | EC50 | J Med Chem (2014) 57: 5370-5380 [PMID:24801499] |
| Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702] | ||||||||
| ChEMBL | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-beta | B | 7.46 | pKd | 35 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| ChEMBL | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR beta | B | 7.82 | pKd | 15 | nM | Kd | Bioorg Med Chem Lett (1999) 9: 589-594 [PMID:10098670] |
| ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor | B | 7.96 | pKd | 11 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR beta | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (1996) 39: 3229-3234 [PMID:8765503] |
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR beta | B | 8.13 | pKi | 7.4 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Agonistic activity towards retinoid X receptor-beta | F | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1997) 40: 4222-4234 [PMID:9435893] |
| ChEMBL | Binding affinity against retinoic Acid X beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR beta | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Binding affinity against retinoic Acid X beta receptors co-transfected into CV-1 cells | B | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Agonist activity for retinoic acid receptor RXR beta in transcriptional activation assay | F | 6.7 | pEC50 | 200 | nM | EC50 | Bioorg Med Chem Lett (1995) 5: 2729-2734 |
| ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay | B | 6.7 | pEC50 | 200 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Transcriptional activation of Retinoid X receptor RXR beta | B | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR beta | F | 7.54 | pEC50 | 29 | nM | EC50 | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| ChEMBL | Effective concentrations against Retinoic acid receptor RXR-beta | B | 8.59 | pEC50 | 2.6 | nM | EC50 | J Med Chem (1995) 38: 3368-3383 [PMID:7650690] |
| Retinoid X receptor-β/Retinoid X receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4047] [GtoPdb: 611] [UniProtKB: P28704] | ||||||||
| ChEMBL | Inhibition of [3H]9-cis-RA binding to mouse Retinoid X receptor RXR beta | B | 7.82 | pKd | 15 | nM | Kd | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Dissociation constant for binding to Retinoid X receptor beta | B | 7.92 | pKd | 12 | nM | Kd | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR beta | B | 6.89 | pEC50 | 128 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443] | ||||||||
| ChEMBL | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-gamma | B | 7.52 | pKd | 30 | nM | Kd | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| ChEMBL | Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor | B | 7.8 | pKd | 16 | nM | Kd | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gamma | B | 7.85 | pKd | 14 | nM | Kd | Bioorg Med Chem Lett (1999) 9: 589-594 [PMID:10098670] |
| ChEMBL | Inhibition of [3H]-9-cis-RA binding to human Retinoid X receptor RXR gamma | B | 7.85 | pKd | 14 | nM | Kd | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
| ChEMBL | Binding affinity towards Retinoic acid receptor RXR-gamma by displacing 3.4 nM 3[H]-9-cis-RA | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 2313-2318 |
| ChEMBL | Inhibition of [3H]targretin binding to Retinoid X receptor RXR gamma | B | 7.85 | pKi | 14 | nM | Ki | J Med Chem (1996) 39: 3229-3234 [PMID:8765503] |
| ChEMBL | Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR gamma | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Agonistic activity towards retinoid X receptor-gamma | F | 7.96 | pKi | 11 | nM | Ki | J Med Chem (1997) 40: 4222-4234 [PMID:9435893] |
| GtoPdb | - | - | 8 | pIC50 | - | - | - |
Proc Natl Acad Sci USA (1993) 90: 30-4 [PMID:8380496]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761]; Cell (1992) 68: 397-406 [PMID:1310260]; Nature (1996) 383: 450-3 [PMID:8837780]; Nature (1992) 355: 359-61 [PMID:1309942]; Genes Dev (1992) 6: 329-44 [PMID:1312497] |
| ChEMBL | Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gamma | F | 6.66 | pEC50 | 219 | nM | EC50 | J Med Chem (1996) 39: 2659-2663 [PMID:8709094] |
| ChEMBL | Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells | B | 6.85 | pEC50 | 140 | nM | EC50 | J Med Chem (1994) 37: 408-414 [PMID:8308867] |
| ChEMBL | Agonist activity for retinoic acid receptor RXR gamma in transcriptional activation assay | F | 6.85 | pEC50 | 140 | nM | EC50 | Bioorg Med Chem Lett (1995) 5: 2729-2734 |
| ChEMBL | Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay | B | 6.85 | pEC50 | 140 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 213-218 |
| ChEMBL | Transcriptional activation of Retinoid X receptor RXR gamma | B | 6.85 | pEC50 | 140 | nM | EC50 | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gamma | F | 8.35 | pEC50 | 4.5 | nM | EC50 | J Med Chem (2001) 44: 2298-2303 [PMID:11428923] |
| ChEMBL | Effective concentrations against Retinoic acid receptor RXR-gamma | B | 8.37 | pEC50 | 4.3 | nM | EC50 | J Med Chem (1995) 38: 3368-3383 [PMID:7650690] |
| Retinoid X receptor-γ/Retinoid X receptor gamma in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4402] [GtoPdb: 612] [UniProtKB: P28705] | ||||||||
| ChEMBL | Dissociation constant for binding to Retinoid X receptor gamma | B | 8.4 | pKd | 4 | nM | Kd | J Med Chem (1996) 39: 3556-3563 [PMID:8784454] |
| ChEMBL | Transcriptional activation in CV-1 cells expressing mouse Retinoid X receptor RXR gamma | B | 6.91 | pEC50 | 124 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 261-264 [PMID:12482435] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
