BMS493 [Ligand Id: 2641] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL472172 (BMS-204493) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] | ||||||||
| ChEMBL | Inverse agonist activity at RARalpha (unknown origin) | B | 6.94 | pIC50 | 114 | nM | IC50 | Bioorg Med Chem (2014) 22: 1285-1302 [PMID:24457093] |
| GtoPdb | - | - | 8.4 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
| Retinoic acid receptor-β in Human [GtoPdb: 591] [UniProtKB: P10826] | ||||||||
| GtoPdb | - | - | 8.54 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
| Retinoic acid receptor-γ in Human [GtoPdb: 592] [UniProtKB: P13631] | ||||||||
| GtoPdb | - | - | 7 | pIC50 | - | - | - | Nature (2002) 415: 187-92 [PMID:11805839] |
| TLX in Human [GtoPdb: 615] [UniProtKB: Q9Y466] | ||||||||
| GtoPdb | Full-length TLX luciferase reporter system in HEK293 cells. | - | 7.27 | pIC50 | 54 | nM | IC50 | Cell Chem Biol (2020) 27: 1272-1284.e4 [PMID:32763139] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
