BMS493 [Ligand Id: 2641] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL472172 (BMS-204493)
  • Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
Created with Highcharts 10.3.3ValuesChart context menuRetinoic acid receptor alphapKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • Retinoic acid receptor-β in Human [GtoPdb: 591] [UniProtKB: P10826]
Created with Highcharts 10.3.3ValuesChart context menuRetinoic acid receptor-βpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • Retinoic acid receptor-γ in Human [GtoPdb: 592] [UniProtKB: P13631]
Created with Highcharts 10.3.3ValuesChart context menuRetinoic acid receptor-γpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • TLX in Human [GtoPdb: 615] [UniProtKB: Q9Y466]
Created with Highcharts 10.3.3ValuesChart context menuTLXpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL Inverse agonist activity at RARalpha (unknown origin) B 6.94 pIC50 114 nM IC50 Bioorg Med Chem (2014) 22: 1285-1302 [PMID:24457093]
GtoPdb - - 8.4 pIC50 - - - Nature (2002) 415: 187-92 [PMID:11805839]
Retinoic acid receptor-β in Human [GtoPdb: 591] [UniProtKB: P10826]
GtoPdb - - 8.54 pIC50 - - - Nature (2002) 415: 187-92 [PMID:11805839]
Retinoic acid receptor-γ in Human [GtoPdb: 592] [UniProtKB: P13631]
GtoPdb - - 7 pIC50 - - - Nature (2002) 415: 187-92 [PMID:11805839]
TLX in Human [GtoPdb: 615] [UniProtKB: Q9Y466]
GtoPdb Full-length TLX luciferase reporter system in HEK293 cells. - 7.27 pIC50 54 nM IC50 Cell Chem Biol (2020) 27: 1272-1284.e4 [PMID:32763139]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]