SB 699551 [Ligand Id: 264] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1181770 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5-HT1AR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT1B receptor/5-hydroxytryptamine receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Binding affinity to 5-HT1BR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT1D receptor/5-hydroxytryptamine receptor 1D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | Binding affinity to 5-HT1DR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity to 5-HT2AR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2B receptor/5-hydroxytryptamine receptor 2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT2C receptor/5-hydroxytryptamine receptor 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Binding affinity to 5-HT2CR (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT3A/5-hydroxytryptamine receptor 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Binding affinity to 5-HT3 (unknown origin) assessed as inhibition constant | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| 5-HT5A receptor/5-hydroxytryptamine receptor 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
| ChEMBL | Binding affinity to human 5-HT5AR | B | 5.7 | pKi | <2000 | nM | Ki | J Med Chem (2022) 65: 4201-4217 [PMID:35195401] |
| GtoPdb | - | - | 8.2 | pKi | 6.3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 4014-8 [PMID:16002289] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
