ChEMBL ligand: CHEMBL41632 (3,5,3'-triiodothyroacetate, Levothyroxine sodium impurity, triiodothyroacetic acid, or t3-acetic acid-, NSC-759294, T3-acetic acid, Tiracana, Tiratricol, TRIAC, Triiodothyroacetic acid)
Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] There should be some charts here, you may need to enable JavaScript!
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
Proliferating cell nuclear antigen in Human [ChEMBL: CHEMBL2346488] [UniProtKB: P12004] There should be some charts here, you may need to enable JavaScript!
Retinoid X receptor-α/Retinoid X receptor alpha in Human [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] There should be some charts here, you may need to enable JavaScript!
OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5] There should be some charts here, you may need to enable JavaScript!
Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827] There should be some charts here, you may need to enable JavaScript!
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828] Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Rat [ChEMBL: CHEMBL3917] [GtoPdb: 589] [UniProtKB: P18113] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL	Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis	B	4.46	pIC50	34800	nM	IC50	J Med Chem (2011) 54: 8563-8573 [PMID:22047606]
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
ChEMBL	Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed by [14C] taurocholate addition and further incubation for 10 mins by scintillation counting method	B	5.16	pIC50	6900	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126623-126623 [PMID:31439379]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetry	B	6.7	pKd	200	nM	Kd	J Med Chem (2020) 63: 6727-6740 [PMID:32356658]
ChEMBL	Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay	B	6.43	pEC50	370	nM	EC50	J Med Chem (2020) 63: 6727-6740 [PMID:32356658]
Proliferating cell nuclear antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2346488] [UniProtKB: P12004]
ChEMBL	Inhibition of human recombinant PCNA interaction with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK after 30 mins by fluorescence polarization assay	B	4.6	pIC50	25000	nM	IC50	Bioorg Med Chem (2013) 21: 1972-1977 [PMID:23395113]
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
ChEMBL	Binding affinity to RXRalpha LBD (unknown origin) by isothermal titration calorimetry	B	5.88	pKd	1320	nM	Kd	J Med Chem (2020) 63: 6727-6740 [PMID:32356658]
ChEMBL	Agonist activity at recombinant human pFA-CMV fused RXRalpha LBD expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay	B	4.92	pEC50	12000	nM	EC50	J Med Chem (2020) 63: 6727-6740 [PMID:32356658]
OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5]
ChEMBL	TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells	F	5.67	pKi	2150	nM	Ki	Endocrinology (2004) 145: 4384-4391 [PMID:15166123]
Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827]
ChEMBL	Inhibition of thyroid hormone receptor alpha	B	9.85	pIC50	0.14	nM	IC50	Bioorg Med Chem (2007) 15: 4609-4617 [PMID:17467994]
ChEMBL	Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor alpha) was determined	B	9.85	pIC50	0.14	nM	IC50	J Med Chem (2003) 46: 1580-1588 [PMID:12699376]
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828]
GtoPdb	-	-	10.7	pKd	-	-	-	Mol Endocrinol (1990) 4: 227-34 [PMID:2158622]
ChEMBL	Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor beta) was determined	B	10.32	pIC50	0.05	nM	IC50	J Med Chem (2003) 46: 1580-1588 [PMID:12699376]
ChEMBL	Inhibition of human thyroid hormone receptor beta 1	B	10.32	pIC50	0.05	nM	IC50	Bioorg Med Chem (2007) 15: 5251-5261 [PMID:17524652]
ChEMBL	Inhibition of thyroid hormone receptor beta	B	10.39	pIC50	0.04	nM	IC50	Bioorg Med Chem (2007) 15: 4609-4617 [PMID:17467994]
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3917] [GtoPdb: 589] [UniProtKB: P18113]
ChEMBL	In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (1995) 38: 695-707 [PMID:7861417]
ChEMBL	In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor	B	9.82	pIC50	0.15	nM	IC50	J Med Chem (1995) 38: 695-707 [PMID:7861417]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]