PPAHV [Ligand Id: 2490] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL104647
1 CHEMBL104647_lig_chart_1 Vanilloid receptor HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL Inhibition of [3H]- RTX binding to Vanilloid receptors from human spinal cord B 5.19 pKi 6400 nM Ki J. Med. Chem. (1996) 39: 3123-3131 [PMID:8759633]
ChEMBL Inhibition of [3H]- RTX binding to Vanilloid receptors from pig spinal cord B 5.68 pKi 2100 nM Ki J. Med. Chem. (1996) 39: 3123-3131 [PMID:8759633]
ChEMBL Inhibitory constant for RTX binding to human spinal cord F 9.35 pKi 0.45 nM Ki J. Med. Chem. (1996) 39: 3123-3131 [PMID:8759633]
ChEMBL Inhibitory constant for RTX binding to porcine spinal cord F 9.92 pKi 0.12 nM Ki J. Med. Chem. (1996) 39: 3123-3131 [PMID:8759633]
TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433]
ChEMBL Inhibition of [3H]- RTX binding to vanilloid receptor of rat urinary bladder F 5.7 pKi 2000 nM Ki J. Med. Chem. (1996) 39: 3123-3131 [PMID:8759633]
ChEMBL Displacement of [3H]RTX binding from Vanilloid receptor of rat dorsal Root Ganglion (DRG) membranes B 6.22 pKi 600 nM Ki J. Med. Chem. (1996) 39: 3123-3131 [PMID:8759633]
ChEMBL Inhibitory constant for RTX binding to rat spinal cord F 10.27 pKi 0.05 nM Ki J. Med. Chem. (1996) 39: 3123-3131 [PMID:8759633]
GtoPdb - - 5.5 pEC50 - - - Br. J. Pharmacol. (2001) 132: 1084-94 [PMID:11226139]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]