ChEMBL ligand: CHEMBL169233 (2-Aminoethoxydiphenyl Borate, 2-(Diphenylboryloxy)Ethanamine)
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit [ChEMBL: CHEMBL4693] [UniProtKB: P04191] There should be some charts here, you may need to enable JavaScript!
TRPM2/Transient receptor potential cation channel subfamily M member 2 in Human [ChEMBL: CHEMBL1250402] [GtoPdb: 494] [UniProtKB: O94759] There should be some charts here, you may need to enable JavaScript!
TRPC3 in Human [GtoPdb: 488] [UniProtKB: Q13507] There should be some charts here, you may need to enable JavaScript!
TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62] There should be some charts here, you may need to enable JavaScript!
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6] There should be some charts here, you may need to enable JavaScript!
TRPM6 in Human [GtoPdb: 498] [UniProtKB: Q9BX84] There should be some charts here, you may need to enable JavaScript!
TRPM7 in Mouse [GtoPdb: 499] [UniProtKB: Q923J1] There should be some charts here, you may need to enable JavaScript!
TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5] There should be some charts here, you may need to enable JavaScript!
TRPV1 in Mouse [GtoPdb: 507] [UniProtKB: Q704Y3] There should be some charts here, you may need to enable JavaScript!
TRPV2 in Mouse [GtoPdb: 508] [UniProtKB: Q9WTR1] TRPV2 in Rat [GtoPdb: 508] [UniProtKB: Q9WUD2] There should be some charts here, you may need to enable JavaScript!
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4693] [UniProtKB: P04191]
ChEMBL	Inhibition of rabbit skeletal muscle microsomes FITC-labelled SERCA1a incubated for 1 hr by fluorescence spectrophotometric method	B	4.15	pIC50	70000	nM	IC50	J Med Chem (2020) 63: 1937-1963 [PMID:32030976]
TRPM2/Transient receptor potential cation channel subfamily M member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250402] [GtoPdb: 494] [UniProtKB: O94759]
ChEMBL	Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp method	B	5.3	pIC50	5000	nM	IC50	Eur J Med Chem (2021) 225: 113750-113750 [PMID:34416664]
ChEMBL	Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiology	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2021) 64: 3976-3996 [PMID:33784097]
ChEMBL	Inhibition of human TRPM2 expressed in HEK293 cells	B	5.92	pIC50	1200	nM	IC50	Eur J Med Chem (2021) 225: 113750-113750 [PMID:34416664]
ChEMBL	Inhibition of human TRPM2 expressed in HEK293 cells	B	6	pIC50	1000	nM	IC50	J Med Chem (2013) 56: 10079-10102 [PMID:24304219]
ChEMBL	Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux by whole cell patch clamp electrophysiology method	B	6	pIC50	1000	nM	IC50	J Nat Prod (2017) 80: 2741-2750 [PMID:29019677]
GtoPdb	-	-	6.1	pIC50	820	nM	IC50	Br J Pharmacol (2008) 153: 1324-30 [PMID:18204483]
TRPC3 in Human [GtoPdb: 488] [UniProtKB: Q13507]
GtoPdb	-	-	5	pIC50	10000	nM	IC50	Mol Pharmacol (2005) 68: 758-62 [PMID:15933213]
TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62]
GtoPdb	-	-	4.7	pIC50	20000	nM	IC50	Br J Pharmacol (2005) 145: 405-14 [PMID:15806115]
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6]
GtoPdb	-	-	4	pIC50	-	-	-	Br J Pharmacol (2005) 145: 405-14 [PMID:15806115]
TRPM6 in Human [GtoPdb: 498] [UniProtKB: Q9BX84]
GtoPdb	-	-	3.7	pEC50	205000	nM	EC50	J Gen Physiol (2006) 127: 525-37 [PMID:16636202]
TRPM7 in Mouse [GtoPdb: 499] [UniProtKB: Q923J1]
GtoPdb	-	-	3.75	pIC50	178000	nM	IC50	J Gen Physiol (2006) 127: 525-37 [PMID:16636202]
TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5]
GtoPdb	-	-	5.1	pIC50	-	-	-	J Biol Chem (2004) 279: 35741-8 [PMID:15194687]; Neurochem Res (2012) 37: 314-20 [PMID:21964764]
TRPV1 in Mouse [GtoPdb: 507] [UniProtKB: Q704Y3]
GtoPdb	-	-	3.9	pEC50	-	-	-	J Biol Chem (2004) 279: 35741-8 [PMID:15194687]
TRPV2 in Mouse [GtoPdb: 508] [UniProtKB: Q9WTR1]
GtoPdb	-	-	3.9	pEC50	129000	nM	EC50	J Biol Chem (2004) 279: 35741-8 [PMID:15194687]; Mol Pharmacol (2007) 72: 1258-68 [PMID:17673572]
TRPV2 in Rat [GtoPdb: 508] [UniProtKB: Q9WUD2]
GtoPdb	-	-	5	pEC50	10000	nM	EC50	J Biol Chem (2007) 282: 15894-902 [PMID:17395593]; J Neurosci (2008) 28: 6231-8 [PMID:18550765]
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
GtoPdb	Patch clamp electrophysiology	-	4.6	pEC50	25100	nM	EC50	J Neurosci (2004) 24: 5177-82 [PMID:15175387]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]