guanosine 5'-diphosphate [Ligand Id: 2410] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL384759 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fucosyltransferase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3146] [UniProtKB: Q11128] | ||||||||
| ChEMBL | Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine | B | 4.17 | pIC50 | 67000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1809-1811 [PMID:11459637] |
| Fucosyltransferase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4985] [UniProtKB: Q9Y231] | ||||||||
| ChEMBL | Inhibition of human recombinant alpha1,3-fucosyltransferase 9 using GDP-[14C]-fucose preincubated for 30 mins by liquid scintillation counting | B | 4.11 | pKi | 77900 | nM | Ki | Bioorg Med Chem (2014) 22: 6430-6437 [PMID:25438767] |
| ChEMBL | Inhibition of human recombinant alpha1,3-fucosyltransferase 9 using GDP-[14C]-fucose preincubated for 30 mins by liquid scintillation counting | B | 4.23 | pIC50 | 59000 | nM | IC50 | Bioorg Med Chem (2014) 22: 6430-6437 [PMID:25438767] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077] | ||||||||
| ChEMBL | Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production | F | 4.35 | pEC50 | 45000 | nM | EC50 | J Med Chem (2006) 49: 5532-5543 [PMID:16942026] |
| Ras-related protein Rab-7a in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105784] [UniProtKB: P51149] | ||||||||
| ChEMBL | Binding affinity to Rab7 GTPase L129F mutant (unknown origin) assessed as equilibrium dissociation constant | B | 6.96 | pKd | 109.2 | nM | Kd | US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (null) |
| ChEMBL | Binding affinity to Rab7 GTPase V162M mutant (unknown origin) assessed as equilibrium dissociation constant | B | 7.04 | pKd | 92.12 | nM | Kd | US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (null) |
| ChEMBL | Binding affinity to Rab7 GTPase N161T mutant (unknown origin) assessed as equilibrium dissociation constant | B | 7.42 | pKd | 37.62 | nM | Kd | US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (null) |
| ChEMBL | Binding affinity to wild-type Rab7 (unknown origin) assessed as equilibrium dissociation constant | B | 7.59 | pKd | 25.83 | nM | Kd | US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (null) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
