spermidine [Ligand Id: 2390] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL19612 (Spermidine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method | B | 5.85 | pKi | 1400 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 12/Carbonic anhydrase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method | B | 4.36 | pKi | 44100 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 13/Carbonic anhydrase 13 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method | B | 4.94 | pKi | 11600 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 14/Carbonic anhydrase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method | B | 6 | pKi | 1000 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 2/Carbonic anhydrase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 5.95 | pKi | 1110 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Carbonic anhydrase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration method | B | 4.94 | pKi | 11500 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 4/Carbonic anhydrase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method | B | 6.95 | pKi | 112 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 5A/Carbonic anhydrase 5A, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method | B | 5.91 | pKi | 1220 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Carbonic anhydrase 5B, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method | B | 5.84 | pKi | 1440 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Carbonic anhydrase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method | B | 5.85 | pKi | 1410 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 7/Carbonic anhydrase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method | B | 5.91 | pKi | 1230 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 9/Carbonic anhydrase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method | B | 5.86 | pKi | 1370 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Coagulation factor XIII A chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4530] [UniProtKB: P00488] | ||||||||
| ChEMBL | Inhibition of human coagulation factor XIIIa assessed as inhibition of factor 13a mediated crosslinking of fibronectin-collagen incubated for 2 hrs by SDS-PAGE analysis | B | 4 | pIC50 | 100000 | nM | IC50 | Eur J Med Chem (2020) 200: 112442-112442 [PMID:32502864] |
| pyruvate kinase M1/2/Pyruvate kinase PKM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618] | ||||||||
| ChEMBL | Inhibition of PKM2 (unknown origin) | B | 5.85 | pIC50 | 1410 | nM | IC50 | J Med Chem (2022) 65: 1171-1205 [PMID:34726055] |
| Kir2.1 in Mouse [GtoPdb: 430] [UniProtKB: P35561] | ||||||||
| GtoPdb | - | - | 8.1 | pKd | - | - | - | Neuron (1995) 14: 1047-54 [PMID:7748552] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
