spermidine [Ligand Id: 2390] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL19612 (Spermidine)
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
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  • pyruvate kinase M1/2/Pyruvate kinase isozymes M1/M2 in Human [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618]
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  • Kir2.1 in Mouse [GtoPdb: 430] [UniProtKB: P35561]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method B 5 pKi 10000 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method B 5.85 pKi 1400 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method B 5.95 pKi 1110 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration method B 4.94 pKi 11500 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method B 6.95 pKi 112 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method B 5.86 pKi 1370 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method B 5.91 pKi 1220 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method B 5.84 pKi 1440 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method B 5.85 pKi 1410 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method B 5.91 pKi 1230 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method B 4.36 pKi 44100 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method B 4.94 pKi 11600 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method B 6 pKi 1000 nM Ki J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
Coagulation factor XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4530] [UniProtKB: P00488]
ChEMBL Inhibition of human coagulation factor XIIIa assessed as inhibition of factor 13a mediated crosslinking of fibronectin-collagen incubated for 2 hrs by SDS-PAGE analysis B 4 pIC50 100000 nM IC50 Eur J Med Chem (2020) 200: 112442-112442 [PMID:32502864]
pyruvate kinase M1/2/Pyruvate kinase isozymes M1/M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618]
ChEMBL Inhibition of PKM2 (unknown origin) B 5.85 pIC50 1410 nM IC50 J Med Chem (2022) 65: 1171-1205 [PMID:34726055]
Kir2.1 in Mouse [GtoPdb: 430] [UniProtKB: P35561]
GtoPdb - - 8.1 pKd - - - Neuron (1995) 14: 1047-54 [PMID:7748552]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizil├Âren T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]