β-alanine [Ligand Id: 2365] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL297569 (3-Amino-Propionic Acid, Beta-Alanine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GAT2/GABA transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4535] [GtoPdb: 930] [UniProtKB: Q9NSD5] | ||||||||
| ChEMBL | Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | B | 4 | pIC50 | >100000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 889-893 [PMID:25147609] |
| GAT3/GABA transporter 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5208] [GtoPdb: 931] [UniProtKB: P48066] | ||||||||
| ChEMBL | Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | B | 4.39 | pIC50 | 41200 | nM | IC50 | Bioorg Med Chem (2013) 21: 4938-4950 [PMID:23886812] |
| ChEMBL | Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | B | 4.39 | pIC50 | 41200 | nM | IC50 | ACS Med Chem Lett (2014) 5: 889-893 [PMID:25147609] |
| GAT2/GABA transporter 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5205] [GtoPdb: 930] [UniProtKB: P31649] | ||||||||
| ChEMBL | Inhibition of mouse GTA 3 receptor | B | 4.18 | pIC50 | 66069.34 | nM | IC50 | Eur J Med Chem (2020) 188: 111920-111920 [PMID:31901745] |
| ChEMBL | Inhibition of GABA uptake at murine GAT-2 expressed in HEK293 cells | B | 4.66 | pIC50 | 21877.62 | nM | IC50 | Eur J Med Chem (2013) 65: 487-499 [PMID:23770450] |
| GAT3/GABA transporter 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3699] [GtoPdb: 931] [UniProtKB: P31650] | ||||||||
| ChEMBL | Inhibition of GABA uptake at murine GAT-3 expressed in HEK293 cells | B | 4.46 | pIC50 | 34673.69 | nM | IC50 | Eur J Med Chem (2013) 65: 487-499 [PMID:23770450] |
| ChEMBL | Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells | B | 4.66 | pIC50 | 21877.62 | nM | IC50 | Eur J Med Chem (2011) 46: 1483-1498 [PMID:21353350] |
| GluN1/Glutamate (NMDA) receptor subunit zeta 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL330] [GtoPdb: 455] [UniProtKB: P35439] | ||||||||
| ChEMBL | Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 of rat spinal cord membranes. | B | 4.94 | pIC50 | 11600 | nM | IC50 | J Med Chem (1992) 35: 233-241 [PMID:1310117] |
| Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8] | ||||||||
| ChEMBL | Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting | B | 0.38 | pKi | -0.38 | mM | pKi | Bioorg Med Chem (2011) 19: 6409-6418 [PMID:21955456] |
| MRGPRD in Human [GtoPdb: 152] [UniProtKB: Q8TDS7] | ||||||||
| GtoPdb | - | - | 4.8 | pEC50 | 15000 | nM | EC50 |
J Biol Chem (2004) 279: 23559-64 [PMID:15037633]; J Biomol Screen (2013) 18: 599-609 [PMID:23396314] |
| MRGPRD in Mouse [GtoPdb: 152] [UniProtKB: Q91ZB8] | ||||||||
| GtoPdb | - | - | 4.36 | pEC50 | 44000 | nM | EC50 | J Biol Chem (2004) 279: 23559-64 [PMID:15037633] |
| MRGPRD in Rat [GtoPdb: 152] [UniProtKB: Q7TN41] | ||||||||
| GtoPdb | - | - | 4.85 | pEC50 | 14000 | nM | EC50 | J Biol Chem (2004) 279: 23559-64 [PMID:15037633] |
| Glycine Receptor (All subtypes) in Human [GtoPdb: 428] | ||||||||
| GtoPdb | - | - | 4.3 | pEC50 | - | - | - | EMBO J (1997) 16: 110-20 [PMID:9009272] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
