ChEMBL ligand: CHEMBL1008 (Bepadin, Bepridil, Vascor)
Anthrax lethal factor in Bacillus anthracis [ChEMBL: CHEMBL4372] [UniProtKB: P15917] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Nav1.5/Sodium channel protein type V alpha subunit in Human [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] There should be some charts here, you may need to enable JavaScript!
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] There should be some charts here, you may need to enable JavaScript!
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit [ChEMBL: CHEMBL2830] [UniProtKB: P15381] There should be some charts here, you may need to enable JavaScript!
KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258] There should be some charts here, you may need to enable JavaScript!
Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Anthrax lethal factor in Bacillus anthracis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4372] [UniProtKB: P15917]
ChEMBL	Protection against Bacillus anthracis lethal toxin-mediated cytotoxicity in mouse RAW264.7 cells assessed as change in viability after 24 hrs by WST1 dye reduction assay	B	5.32	pIC50	4800	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2403-2411 [PMID:17485504]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Displacement of [3H]Astemizole from hERG expressed in HEK293 cells at 10 uM	B	6.35	pKi	444	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5303-5308 [PMID:16908150]
ChEMBL	Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA	B	6.54	pKi	291	nM	Ki	J Med Chem (2007) 50: 2931-2941 [PMID:17536794]
ChEMBL	Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay	B	6.74	pKi	184	nM	Ki	J Med Chem (2007) 50: 2931-2941 [PMID:17536794]
ChEMBL	Inhibition of human ERG expressed in HEK293 cells measured after 30 mins by FluxOR dye based FLIPR TETRA assay	B	5.85	pIC50	1400	nM	IC50	J Med Chem (2020) 63: 5734-5751 [PMID:32392053]
ChEMBL	K+ channel blocking activity in COS-7 African green monkey kidney derived cells expressing HERG Kv11.1	F	6.26	pIC50	550	nM	IC50	J Med Chem (2002) 45: 3844-3853 [PMID:12190308]
ChEMBL	Inhibition of human Potassium channel HERG expressed in mammalian cells	B	6.26	pIC50	549.54	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL	Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique	B	6.26	pIC50	549.54	nM	IC50	Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL	Inhibition of human ERG in MCF7 cells	B	6.26	pIC50	549.54	nM	IC50	Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341]
ChEMBL	Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state	F	6.26	pIC50	549.54	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831]
ChEMBL	Inhibitory concentration against potassium channel HERG	B	6.26	pIC50	549.54	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	6.37	pIC50	430	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL	Inhibition of hERG K channel	F	7.48	pIC50	33	nM	IC50	Cardiovasc Res (2011) 91: 53-61 [PMID:21300721]
ChEMBL	Inhibition of human ERG	B	7.64	pIC50	22.91	nM	IC50	Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against Plasmodium falciparum	F	5.6	pIC50	2500	nM	IC50	Antimicrob Agents Chemother (2007) 51: 2403-2411 [PMID:17485504]
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
ChEMBL	Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA	F	5.43	pIC50	3700	nM	IC50	Cardiovasc Res (2011) 91: 53-61 [PMID:21300721]
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
ChEMBL	Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes	F	5.59	pIC50	2600	nM	IC50	J Appl Toxicol (2012) 32: 858-866 [PMID:22761000]
ChEMBL	Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in guinea pig atrial myocytes	F	5.81	pIC50	1550	nM	IC50	IC50 data for the L-type calcium channel extracted from a set of literature articles
ChEMBL	Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes	F	6.3	pIC50	500	nM	IC50	J Appl Toxicol (2012) 32: 858-866 [PMID:22761000]
ChEMBL	Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes	F	6.68	pIC50	211	nM	IC50	Cardiovasc Res (2011) 91: 53-61 [PMID:21300721]
ChEMBL	Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes	F	6.68	pIC50	211	nM	IC50	J Appl Toxicol (2012) 32: 858-866 [PMID:22761000]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
ChEMBL	Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit	F	5.85	pIC50	1400	nM	IC50	J Appl Toxicol (2012) 32: 858-866 [PMID:22761000]
Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381]
ChEMBL	Inhibition of [3H]nitrendipine binding to calcium channels in Rabbit cardiac muscle.	B	4.66	pIC50	22000	nM	IC50	J Med Chem (1988) 31: 2221-2227 [PMID:3184128]
KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258]
GtoPdb	-	-	6	pIC50	-	-	-	Neuropharmacology (2006) 51: 896-906 [PMID:16876206]
Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696]
GtoPdb	-	-	5	pIC50	-	-	-	Am J Physiol, Cell Physiol (2001) 280: C859-66 [PMID:11245603]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]