senicapoc [Ligand Id: 2331] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL405821 (ICA-17043, PF-05416266, Senicapoc) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
| ChEMBL | Inhibition of gardos channel (unknown origin) | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| ChEMBL | Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2008) 51: 976-982 [PMID:18232633] |
| GtoPdb | - | - | 7.96 | pIC50 | 11 | nM | IC50 | Blood (2003) 101: 2412-8 [PMID:12433690] |
| ChEMBL | Inhibition of Kca 3.1 (unknown origin) | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv1.5/Potassium voltage-gated channel subfamily A member 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| ChEMBL | Inhibition of voltage-gated K channel 1.5 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv7.1/Potassium voltage-gated channel subfamily KQT member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787] | ||||||||
| ChEMBL | Inhibition of voltage-gated K channel 7.1 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Protein Red in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321616] [UniProtKB: Q13123] | ||||||||
| ChEMBL | Inhibition of IK (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.1/Sodium channel protein type 1 subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1845] [GtoPdb: 578] [UniProtKB: P35498] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.1 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.2/Sodium channel protein type 2 subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4187] [GtoPdb: 579] [UniProtKB: Q99250] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.2 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.3/Sodium channel protein type 3 subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5163] [GtoPdb: 580] [UniProtKB: Q9NY46] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.3 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.4/Sodium channel protein type 4 subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2072] [GtoPdb: 581] [UniProtKB: P35499] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.4 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.6/Sodium channel protein type 8 subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5202] [GtoPdb: 583] [UniProtKB: Q9UQD0] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.6 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Nav1.7/Sodium channel protein type 9 subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858] | ||||||||
| ChEMBL | Inhibition of voltage-gated Na channel 1.7 (unknown origin) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG channel | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
